Benchmarking the neurophysiology of human cortex models in vitro

该项目旨在通过开发一种分析工具来改进体外人类大脑模型，以确定与成人大脑皮层的生物物理相似性。该项目希望通过首次在体外测试整合样感觉输入和清醒/睡眠样电活动周期的理论来产生新的知识，这可能会完成人脑类器官模型的成熟。它还将产生新的方法来简化多模态路径箝位数据（Patch-seq）的分析。预期的结果将促进研究合作和精确的人类大脑实验复制的可重复性。这将为理解人类大脑计算机制的全球竞赛提供重大好处。

This project aims to improve human brain models in vitro by developing an analytical tool benchmarking biophysical similarities to the adult human cortex. This project expects to generate new knowledge by testing for the first time the theory that integrating sensory-like inputs and awake/sleep-like cycles of electrical activity in vitro may complete the maturation of human brain organoid models. It will also generate new methods to simplify the analysis of multimodal path-clamping data (Patch-seq). Expected outcomes will facilitate research collaboration and the reproducibility of accurate experimental replicates of the human brain. This will provide significant benefits in the global race to understand human brain computation mechanisms.