A combined nanotechnology and surgical strategy to treating liver cancer

肝癌目前很难治疗，成功治疗这种癌症所需的化疗药物量很高。在这个项目中，我们计划将肝脏从宿主体内移除，并向肝脏注入一种纳米颗粒，这种纳米颗粒含有抗癌药物5-氟尿嘧啶，可以靶向巨噬细胞肿瘤浸润性细胞。这些细胞支持肿瘤系统的生存。这种纳米容器注入的肝脏将被重新植入动物体内。纳米颗粒在2-3周后分解，释放药物，杀死巨噬细胞肿瘤浸润性细胞，从而摧毁肿瘤。这应该会增加动物的存活率。我们的商业合作伙伴专门开发可以靶向肝癌细胞的药物和蛋白质。将治疗生物医学研究所的专业知识与来自学术方面的纳米技术、肝脏、外科和物理学研究人员的独特专业知识相结合，将产生治疗肝癌的新策略。

Liver cancer is currently difficult to treat and the required amount of chemotherapeutics to successfully treat this cancer ishigh. In this project, we plan to remove the liver from the host and infuse the liver with a nanoparticle that contains thecancer-fighting drug 5-fluorouracil and that can target macrophage tumor infiltrating cells. These cells support the survival ofthe tumor system. This nanocontainer infused liver will be re-implanted into the animal. The nanoparticle breaks apart after2-3 weeks to release the drug and kill the macrophage tumor infiltrating cells and therefore, destroying the tumor. Thisshould lead to an increase in the survival of the animal. Our commercial partner specializes in developing drugs and proteinsthat can target liver cancer cells. Combining the expertise of the Therapure Biopharma with the unique expertise ofresearchers in nanotechnology, liver, surgery, and physics from the academic side will lead to new strategies to treat livercancer.