Preventing Adverse Tissue Reactions in Total Hip Replacement, from Mechanisms to New Implant Designs

骨关节炎（OA）是一种影响十分之一加拿大成年人的关节疾病。晚期OA导致持续疼痛和活动能力丧失。目前最有效的治疗方法是全髋关节置换术，用合成材料（如金属）制成的假体代替受损的关节。不幸的是，最近发现大量患者对一些最新的植入物发生了局部不良组织反应（ALTR），导致广泛的软组织损伤，需要进行翻修手术。这一最新进展引起了生物医学界和接受髋关节置换术的患者的严重关注。在这个合作研究项目中，经验丰富的外科医生将与病理学家、微生物学家、细胞生物学家和材料工程师以及行业合作伙伴密切合作，通过一系列临床和实验室研究，揭示局部不良组织反应的基本机制和主要原因。将开发新的材料技术，以尽量减少不良组织反应。该项目的进展将通过更好的治疗技术和植入技术直接转化为改善患者护理。

Osteoarthritis (OA) is a joint disease affecting one in ten Canadian adults. Late stage OA leads to constant pain and loss ofmobility. The most effective treatment today is total hip arthroplasty that replaces the damaged joints with prostheses madefrom synthetic materials such as metals. Unfortunately, it has been discovered lately that a significant number of patientshave developed Adverse Local Tissue Reactions (ALTR) to some of the latest implants, resulting in extensive soft tissuedamage that requires revision surgeries. This latest development has caused serious concerns to the biomedical communityand the patients undergoing hip replacement. In this collaborative research project, experienced surgeons will work closelywith a group of pathologists, microbiologists, cell biologist and materials engineers, as well as industry partners, to uncoverthe fundamental mechanisms and primary causes of the Adverse Local Tissue Reactions through a series of clinical andlaboratory studies. New material technologies will be developed to minimize the adverse tissue reactions. Progress in thisproject will be directly translated into improved patient care through better treatment techniques and implant technologies.