The multifaceted roles of PLK4

多年来精心计划和进行的实验已经确定，一种名为Polo like kinase4(Plk4)的蛋白质是中心体复制的主要调节因子。中心体是一种小细胞器，它参与确保细胞中的遗传信息在细胞分裂时平等传递。Plk4是一组被称为激酶的蛋白质中的一员。这些蛋白质改变结构，从而改变它们相互作用的蛋白质的功能或活性。我们和其他人专注于确定Plk4水平的变化，无论是由于增加还是减少，对细胞都有有害的影响。Plk4在发育过程中起着重要的作用，因为小鼠缺乏一个等位基因

Years of carefully planned and carried out experiments has determined that the protein called Polo like kinase 4 (PLK4), is a major regulator of centrosome duplication. Centrosomes are small organelles, which are involved in ensuring that the genetic information in cells is passed on equally when a cell divides. PLK4 is a member of a group of proteins known as kinases. These proteins modify the structure and thereby the function or activity of proteins that they interact with. We and others have focused on establishing that alterations of PLK4 levels, either due to an increase or a decrease, have a detrimental effect on cells. PLK4 plays an important role during development, as mouse lacking one allele of