Transport and Metabolism in Fish

在一个拥有世界上最长海岸线的国家，拥有世界上17的淡水，以及一个鱼类和渔业每年贡献超过170亿美元的经济体（运动捕鱼约100亿美元，商业捕鱼约60亿美元，水产养殖约10亿美元），了解鱼类的基本生理学和保护自然沃茨健康的重要性怎么强调都不过分。本申请在长期研究计划中开辟了新的前沿，该长期研究计划旨在了解鱼类中营养物质、废物、离子、酸碱当量和呼吸气体的运输和代谢所涉及的机制，以及这些过程如何被环境条件和生物学改变。该基础研究计划支持水生毒理学，水产养殖和环境管理的平行应用程序。同时在分子、细胞、器官系统、整个动物和行为水平上分析机制。对物种（鳟鱼、鳉鱼、鲨鱼、盲鳗、斑马鱼等）采用比较方法。压力源（氨，O

In a country with the longest coastline in the world, with 1/7 of the world’s freshwater, & an economy where fish and fisheries contribute over $17B annually (sportfishing ~ $10B, commercial fishing ~ $6B, aquaculture ~ $1B), the importance of understanding the basic physiology of fish & protecting the health of natural waters cannot be overstated. The present application opens new frontiers in a long term research program aimed at understanding the mechanisms involved in the transport & metabolism of nutrients, wastes, ions, acid-base equivalents, & respiratory gases in fish, & how these processes are modified by environmental conditions & phylogeny. This basic research program underpins a parallel applied program in aquatic toxicology, aquaculture, & environmental management. Mechanisms are analyzed at molecular, cellular, organ system, whole animal, & behavioral levels simultaneously. A comparative approach is used with respect to species (trout, killifish, sharks, hagfish, zebrafish etc.) & stressors (ammonia, O