Solid-State NMR Across the Periodic Table: Methods and Applications

固体核磁共振（SSNMR）光谱是表征分子水平结构和动力学的最强大的技术。NMR光谱比任何其他类型的光谱对结构差异和变化更敏感，这使得NMR在化学，生物化学，物理学和材料科学中的应用非常宝贵。然而，它的主要缺点是它的灵敏度：由于NMR是一种非常低的能量光谱，它可能需要很长时间才能获得高信噪比（S/N）的光谱。直到最近，获取元素周期表中许多核素（约80%）的NMR谱还是非常困难的（或在某些情况下是不可能的）-这些被统称为不受欢迎的NMR核素。事实上，NMR的圣杯之一是解决低灵敏度的问题，这将使NMR实验对更广泛的材料开放，并减少传统NMR实验的时间范围。

Solid-state NMR (SSNMR) spectroscopy is the most powerful technique for the characterization of molecular-level structure and dynamics. NMR spectra are more sensitive to structural differences and changes than any other type of spectroscopy, which makes NMR invaluable for use in chemistry, biochemistry, physics and materials science. However, its major shortcoming is its sensitivity: since NMR is a very low energy spectroscopy, it can take a long time to acquire spectra with high signal-to-noise (S/N) ratios. Until recently, it was very difficult (or in some cases impossible) to acquire NMR spectra for many of the nuclides of the elements in the periodic table (about 80%) - these are collectively known as unreceptive NMR nuclides. Indeed, one of the holy grails of NMR is to solve the problem of low sensitivity, which would open NMR experimentation to a much broader range of materials, as well as reducing the time frames of conventional NMR experiments.