Ultra-fast magic-angle spinning (UFMAS) NMR probe

超快魔角旋转 (UFMAS) NMR 探头

• 批准号: 360013-2008
• 负责人: Schurko, Robert
• 金额: $ 8.11万
• 依托单位: University of Windsor
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=364300
• 关键词: Ultra; fast; magic; angle; spinning

Solid-state nuclear magnetic resonance (NMR) has become one of the most useful techniques for characterizing solid materials at the molecular level.  Whereas many techniques are restricted to the types of solid materials that can be studied, solid-state NMR is the most versatile, and can be applied to study crystalline materials, glasses and disordered materials, composite materials, metal/semi-metal alloys, biomembranes, proteins, drugs, agricultural products, polymers, etc.  Characterizing such solid materials at the molecular level gives researchers insight into the rational design of new materials and the atomic origins of the bulk properties of materials; such understanding has and will continued to have enormous scientific, technological and economic impact.Magic-angle spinning (MAS) is one of the primary techniques utilized in solid-state NMR, whereby the sample rotor is spun rapidly about an axis oriented at 54.74 degrees from the superconducting magnetic field.  The effect of this rotation is two average the broad NMR interactions observed in solid-state NMR spectra, and to produce sharp, high signal-to-noise, high-resolution NMR spectra comparable to those observed for solutions.  Conventional NMR probes spin from 1 to 35 kHz, and are useful for a large number of different experiments and samples; however, there are limitations.We are proposing to purchase an ultra-fast magic-angle spinning (UFMAS) probe which can spin from 10 to 65 kHz.  This probe, which will be a unique configuration in Canada, will allow us to probe nuclei across the periodic table, and acquire ultra-high resolution NMR spectra of a variety of materials, including nanoparticles, pharmaceuticals, catalytic materials, liquid crystals and organic semi-conductors.  The 1.1 mm outside diameter sample rotors have a tiny sample volume of 1.2 uL, allowing us to work on very small sample sizes.  The tiny probe coil will produce enormous radiofrequency fields, allowing to acquiring high resolution spectra of 1H, 13C, 15N, 19F, 29Si, 31P, 35Cl, etc. nuclei in a myriad of solid samples.

固体核磁共振（NMR）已成为在分子水平上表征固体材料的最有用的技术之一。虽然许多技术仅限于可以研究的固体材料类型，但固态核磁共振是最通用的，可以应用于研究晶体材料，玻璃和无序材料，复合材料，金属/半金属合金，生物膜，蛋白质，药物，农产品，聚合物等。在分子水平上表征这种固体材料使研究人员能够深入了解新材料的合理设计和材料体积特性的原子起源；这种理解已经并将继续产生巨大的科学、技术和经济影响。魔角旋转（MAS）是固态核磁共振中使用的主要技术之一，通过该技术，样品转子围绕与超导磁场定向54.74度的轴快速旋转。这种旋转的影响是在固态核磁共振光谱中观察到的两种广泛的核磁共振相互作用的平均，并产生与观察到的溶液相媲美的尖锐、高信噪比、高分辨率的核磁共振光谱。传统的核磁共振探针自旋从1到35千赫，并适用于大量不同的实验和样品；然而，也有局限性。我们建议购买一种超快速魔角旋转（UFMAS）探针，其旋转频率为10至65千赫。该探针将是加拿大独特的配置，将使我们能够探测元素周期表中的原子核，并获得各种材料的超高分辨率核磁共振光谱，包括纳米颗粒，药物，催化材料，液晶和有机半导体。外径1.1毫米的样品转子具有1.2 uL的微小样品体积，使我们能够在非常小的样品尺寸上工作。微小的探针线圈将产生巨大的射频场，可以在无数固体样品中获得1H， 13C, 15N, 19F, 29Si, 31P， 35Cl等原子核的高分辨率光谱。