The physical underpinnings of intrinsically disordered proteins: conformations, dynamics and interactions
The physical underpinnings of intrinsically disordered proteins: conformations, dynamics and interactions
批准号:
RGPIN-2017-06030
负责人:
Gradinaru, Claudiu
金额:
$3.28万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-01-01 至 2018-12-31
中文摘要
复杂的动力学行为决定了蛋白质功能的许多关键方面。与癌症和神经退行性疾病有关的内源性无序蛋白(IDP)在纳秒至毫秒的时间尺度上表现出构象变化,这对其调节机制至关重要。尽管近年来对国内流离失所者问题进行了多学科的密切关注,但仍然缺乏对其结构紊乱的物理机制及其相互作用的动态性质的合理理解。
英文摘要
Complex dynamic behavior dictates many key aspects of protein function. Intrinsically disordered proteins (IDPs), which are involved in cancer and neurodegenerative diseases, exhibit conformational changes on nanosecond to millisecond timescales which are essential for their regulatory mechanisms. Despite an intense multidisciplinary focus on IDPs in recent years, a reasonable understanding of the physical mechanisms underlying their structural disorder and the dynamic nature of their interactions is still lacking.
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The physical underpinnings of intrinsically disordered proteins: conformations, dynamics and interactions
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批准号:RGPIN-2017-06030
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项目类别:Discovery Grants Program - Individual
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资助金额:$6.56万
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财政年份:2021
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负责人:Gradinaru, Claudiu
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依托单位:
The physical underpinnings of intrinsically disordered proteins: conformations, dynamics and interactions
-
批准号:RGPIN-2017-06030
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.28万
-
财政年份:2020
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负责人:Gradinaru, Claudiu
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依托单位:
The physical underpinnings of intrinsically disordered proteins: conformations, dynamics and interactions
-
批准号:RGPIN-2017-06030
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.28万
-
财政年份:2019
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负责人:Gradinaru, Claudiu
-
依托单位:
The physical underpinnings of intrinsically disordered proteins: conformations, dynamics and interactions
-
批准号:RGPIN-2017-06030
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.28万
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负责人:Gradinaru, Claudiu
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依托单位:
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Proteins in Motion: Measuring Disorder and Interactions at Single Molecule Level
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依托单位:
Proteins in Motion: Measuring Disorder and Interactions at Single Molecule Level
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资助金额:$1.82万
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依托单位:
Proteins in Motion: Measuring Disorder and Interactions at Single Molecule Level
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批准号:342295-2012
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项目类别:Discovery Grants Program - Individual
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资助金额:$1.82万
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依托单位:
Proteins in Motion: Measuring Disorder and Interactions at Single Molecule Level
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批准号:342295-2012
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项目类别:Discovery Grants Program - Individual
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资助金额:$1.82万
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Watching proteins fold one at a time
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依托单位:
Watching proteins fold one at a time
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批准号:342295-2007
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.15万
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依托单位:
Watching proteins fold one at a time
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批准号:342295-2007
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.15万
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依托单位:
Watching proteins fold one at a time
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批准号:342295-2007
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.15万
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财政年份:2008
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负责人:Gradinaru, Claudiu
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依托单位:
Watching proteins fold one at a time
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批准号:342295-2007
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.15万
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负责人:Gradinaru, Claudiu
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依托单位:
海外基金