Aerosol Deposition Measurements and Numerical Simulations in Extra-thoracic Airways using the Respimat® Inhaler with an ODAPT(TM) Add-on Mask Adapter

MMSI(McArthur Medical Sales Inc.，Rockton，On)开发了一种附加适配器，将Respimat吸入器连接到市场上可买到的口罩上，这将促进某些患者(通常是老年人和儿童)吸入ASTMA药物，这些患者通常在驱动和吸入之间缺乏协调。将在体外(间接使用理想化的口-喉-气管复制品)研究适配器(和面罩)对吸入性能(给肺的药物输送)的影响，并与单独使用Respimat吸入器的效率进行比较。采用雷诺平均N-S方程(RANS)或分离涡模拟(DES)对单相流和颗粒相采用拉格朗日随机游动涡旋相互作用模型(EIMS)进行了沉积数值模拟，并与实验数据进行了验证。

MMSI (McArthur Medical Sales Inc., Rockton, ON) developed an add-on adapter to connect the Respimatinhaler to commercially available masks that will facilitate the inhalation of ashtma medication by certainpatients, normally seniors and children, who may normally lack coordination between actuation and inhalation.The effect of introducing the adapter (and mask) on the inhalation performance (medication delivery to thelungs) will be investigated in-vitro (indirectly using idealized mouth-throat-trachea replicas) and comparedagainst the efficiency of the Respimat inhaler alone. Deposition numerical simulations usingReynolds-Averaged Navier-Stokes (RANS) equations or DES (Detached Eddy Simulation) for the single phaseflow and Lagrangian random walk eddy interaction models (EIMs) for the particulate phase will also beperformed and the results will be validated against the experimental data.