Quantification of the real-time near-infrared spectroscopic tissue oxygenation index using venous saturation in presence of cyclic muscular motion

近红外光谱(NIRS，也称为漫反射光谱)是一种使用近红外光来测量身体组织(如肌肉和大脑)的血流和新陈代谢的技术。近红外线是非侵入性的，人类看不见，也不电离(也就是说，它不会致癌，不像紫外线)。运动过程中肌肉新陈代谢的一个重要组成部分是氧气消耗，科学家可以测量它，以确定肌肉对运动的反应，以及一个人是否从运动中受益。肌肉氧利用的标准测量之一是组织氧合指数，或TOI。然而，用于确定TOI的方法在不同的NIRS仪器上没有标准化，这限制了其广泛的适用性和不同实验室和体育科学家所做评估的一致性。本研究的目的是建立一种在存在循环运动的情况下利用静脉饱和度计算TOI的新方法。这将允许在脉搏血氧仪中使用成熟和有效的技术，将其应用于近红外光谱。静脉饱和度可以无创性地测量，这使得可以使用黄金标准来校准方法。这将提高在许多环境中用于运动测试的近红外仪器的一致性和准确性。

Near-infrared spectroscopy (NIRS, also known as diffuse optical spectroscopy) is a technique that usesnear-infrared light to measure blood flow and metabolism in body tissues like muscle and brain. NIRS isnon-invasive, invisible to humans, and non-ionizing (that is, it does not cause cancer, unlike ultraviolet light).An important component of muscle metabolism during exercise is oxygen consumption, which scientists canmeasure in order to determine how muscle is responding to exercise and whether a person is benefiting fromthe exercise. One of the standard measurements of muscle oxygen use is the tissue oxygenation index, or TOI.However, the methods used to determine TOI are not standardized across different NIRS instruments, and thislimits both its wide applicability and the consistency of the assessments done by various laboratories and sportscientists. The goal of this research is to establish a new method for calculating TOI using the venoussaturation in presence of cyclic motion. This will allow use of well established and validated techniques inpulse oximetry to be applied to NIRS. Venous saturation can be measured invasively which allows calibrationof the method using a gold standard. This will improve the consistency and accuracy of NIRS instruments thatare used for exercise testing in many settings.