Nutritional regulation of skeletal muscle development and breast muscle myopathies in broiler chickens

禽肉消费量很大，主要是由于其健康益处，烹饪方便，价格合理。近年来，现代家禽养殖业中肌病的发生率引起了全球的关注，其中包括白色条纹和木质胸。这些肌病对胸肉的视觉外观和营养价值以及消费者的感知产生负面影响。有这些缺陷的肉在加工厂被降级甚至丢弃，给家禽业造成了相当大的经济损失。有必要为未来的研究，以阐明肌肉缺陷的病因，然后制定遗传，营养和/或管理策略，以改善肉仔鸡的肉质。考虑到Wallenstein Feed & Supply Ltd.的主要市场之一是家禽饲料，这是一个开发预防肉鸡出现白色条纹和木质乳房的营养解决方案的机会。因此，Wallenstein Feed & Supply Ltd.决定与Yang实验室合作，研究肉鸡骨骼肌发育和胸肌肌病的营养调控。就目前的项目而言，确定了两个具体目标。目的1：利用鸡肌肉细胞建立体外氧化应激和炎症模型。对于目标2，我们将确定不同饲料成分和CaSR拮抗剂对鸡肌肉细胞中氧化应激和炎症的影响。拟议的Engage项目将支持Wallenstein Feed & Supply Ltd.和Yang实验室之间的初步研究和桥梁关系。这笔资金将产生关于推定机制的新知识，这些机制可能构成未来伙伴关系计划应用的基础（即：NSERC CRD）。

Poultry meat has been highly consumed mainly due to its health benefit, convenience in cooking, and reasonable cost. Recently, global attention has been drawn to the incidence of myopathies in modern poultry industry, including white striping and woody breast. These myopathies negatively affect the visual appearance, and nutritional value of the breast meat and consumer perception. Meat with these defects is downgraded or even discarded in the processing plant, leading to considerable economic loss to the poultry industry. There is a need for future research to elucidate the etiology of the muscle defects and then develop genetic, nutritional and /or management strategies to improve the broiler meat quality. Considering that one of primary markets for Wallenstein Feed & Supply Ltd. is poultry feed, it is an opportunity to develop nutritional solutions for preventing white striping and woody breast in broilers. Therefore, Wallenstein Feed & Supply Ltd. has decided to partner with the Yang lab to investigate the nutritional regulation of skeletal muscle development and breast muscle myopathies in broilers. For the current project, two specific objectives have been established. For Objective 1, we will establish in vitro oxidative stress and inflammation models using chicken muscle cells. For Objective 2, we will determine the effect of different feed ingredients and CaSR antagonists on oxidative stress and inflammation in chicken muscle cells. The proposed Engage project will support preliminary research and bridge relations between Wallenstein Feed & Supply Ltd. and the Yang laboratory. This funds will yield new knowledge about putative mechanisms that may form the basis of future partnership program applications (ie: NSERC CRD).