Targeted DNA demethylation based therapeutics.
Targeted DNA demethylation based therapeutics.
批准号:
380053
负责人:
Szyf Moshe
金额:
$53.22万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2018
资助国家:
加拿大
项目状态:
已结题
起止时间:
2018-03-01 至 2023-03-01
中文摘要
背景资料。DNA甲基化是DNA上的一种“表观遗传”化学标记,它对“生命之书”进行标点和“编程”。Szyf实验室率先提出,不同的环境经历会改变DNA甲基化,而DNA甲基化的变化
英文摘要
Background. DNA methylation is an "epigenetic" chemical mark on DNA that punctuates and "programs" the "book of life". The Szyf lab pioneered the idea that different environmental experiences change DNA methylation and that changes in DNA methylation are
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会议论文
Impact of Early life MetaBolic and psychosocial strEss on susceptibility to mental Disorders; from converging epigenetic signatures to novel targets for therapeutic intervention
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批准号:387208
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项目类别:Operating Grants
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资助金额:$5.46万
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财政年份:2018
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负责人:Szyf Moshe
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依托单位:
Mechanism of action of DNMT1 inhibitors; a pharmacoepigenomic analysis
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批准号:259684
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项目类别:Salary Programs
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资助金额:$24.04万
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财政年份:2012
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负责人:Szyf Moshe
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依托单位:
Mechanisms of action of DNA demethylation inhibition as a therapeutic strategy against liver cancer
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批准号:229020
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项目类别:Operating Grants
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资助金额:$16.39万
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财政年份:2011
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负责人:Szyf Moshe
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依托单位:
Mechanism of action of DNA methyltransferase (DNMT1) inhibitors and their therapeutic potential
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批准号:200288
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项目类别:Operating Grants
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资助金额:$71.62万
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财政年份:2010
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负责人:Szyf Moshe
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依托单位:
Whole epigenome profiling of the epigenetic marks of maternal depression and its impact on the offspring epigenome.
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批准号:196312
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项目类别:Operating Grants
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资助金额:$36.43万
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财政年份:2009
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负责人:Szyf Moshe
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依托单位:
海外基金