Exploration of new chemicals to enable rapid functionalization of pharmaceuticals**

Paraza Pharma打算使药物分子/中间体多样化，以进行快速结构-活性-关系(SAR)研究。然而，目前的方法缺乏许多功能基团的配伍性，而这些官能团通常存在于药物中间体中。此外，许多药物感兴趣的片段需要多个步骤才能引入到药物中间体中。拟议的项目将使用最近在李朝军教授的实验室中发现的新的烷基化反应来解决这个问题。该项目将寻求新的化学物质，使先进的药物一步实现功能化。这项研究将集中于优化反应条件，使化学选择性和官能团可容忍的转化成为可能。*这一拟议项目的成功将是制药业研究和开发方面的重大进步。**

Paraza Pharma intends to diversify pharmaceutical molecules/intermediates for rapid Structure-Activity-Relationship (SAR) studies. However, the current methodologies lacks the compatibility of many functional groups which usually exist in advance pharmaceutical intermediate. Furthermore, many pharmaceutical interesting fragments requires multiple steps to be introduced into the pharmaceutical intermediates. The proposed project will address this problem using novel alkylating reactions recently discovered in Professor Chao-Jun Li's laboratory. The project will pursue new chemical matters which will allow the functionalization of advance pharmaceuticals in one step. The research will be focusing on optimizing reaction conditions to allow chemo-selective and functional group tolerable transformation possible. ****The success of this proposed project will be a significant advancement in pharmaceutical industry research and development.**