Paper-based diagnostic device for colorectal cancer detection

结直肠癌（CRC）影响全球100多万人，每年导致约60万人死亡**。早期发现结直肠癌可显著降低结直肠癌的死亡率。局部包含肿瘤病变时发现**，5年生存率**大于90%；当它们扩散到附近的淋巴结或远处的器官时，发病率分别下降到69%和12%。结直肠癌筛查的金标准是结肠镜检查；虽然这种方法是有效的，但它是昂贵和侵入性的，并可能导致并发症。侵入性或非侵入性较低的方法要么容易出现假阳性结果，需要结肠镜随访，要么作为筛查工具非常昂贵。在这个**合作项目中，一个由学术研究人员和临床医生组成的团队将共同努力**开发一种简单的、石蕊试纸状的用于CRC无创检测的纸装置。该测试**适用于使用粪便样本进行常规结直肠癌筛查。如果成功，这样的测试将有助于拯救加拿大和世界各地的生命。

Colorectal cancer (CRC) affects over a million people globally, resulting in ~600,000 deaths**annually. Early detection of CRC can significantly reduce the mortality of CRC. When**neoplastic lesions are found while they are locally contained, the 5-year survival rate is**greater than 90%; when they spread to nearby lymph nodes or distant organs, the rate drops**to 69% and 12%, respectively. The gold standard for CRC screening is colonoscopy; while**this procedure is effective, it is expensive and invasive, and can cause complications. Less**invasive or non-invasive methods are either prone to false-positives that require**follow-up with colonoscopy or very expensive to be used as a screening tool. In this**collaborative project, a team of academic researchers and clinicians will work together to**develop a simple, litmus paper-like paper device for non-invasive detection of CRC. The test**will be suited for routine CRC screening using stool samples. If successful, such a test will**help save lives in Canada and around the world.