Advanced Microfluidic Nanobiosensing

不断改进现有分析平台的需求（例如，在更低的成本，更高的性能和更好的可及性方面）要求开发新的生物传感技术，用于分子诊断，环境监测和食品检测等应用。微流控和芯片实验室技术由于其独特的能力，如并行样品操作，芯片上的生物传感器集成和敏感的分析物检测，为创建强大的生物传感平台提供了巨大的希望。该研究项目旨在开发新的微流控纳米生物传感技术，该技术集成了两种新兴的纳米材料-纳米纤维化纤维素（NFC）和二硫化钼（MoS2）。研究将集中在新型纳米生物传感器的设计和微制造，功能纳米材料的片上合成和集成，新的生物分析方法的研究，以及设备性能的优化和表征。所提出的生物传感平台将继承微流体器件和基于纳米材料的生物传感器的优点，从而进一步推动生物传感技术的发展。******该计划将导致创新的纳米生物传感技术，新的理论模型和设计指南，以及适合实际应用的第一种纳米生物传感器原型。这些高性能生物传感平台将立即应用于医疗诊断和水/食品检测，从而有利于加拿大社会的健康和经济。该计划还将为17名高素质人才（4名博士生，3名硕士生和10名本科生）提供跨学科培训，使他们具备将所获得的知识应用于长期影响和领导微流体和生物传感新举措所需的学术和专业技能。

The demands for continuously improving current analytical platforms (e.g., in terms of lower cost, higher performance, and better accessibility) require new biosensing technologies to be developed for applications such as molecular diagnosis, environmental monitoring, and food testing. Microfluidic and lab-on-a-chip technologies hold great promise for creating powerful biosensing platforms because of their unique capabilities such as parallel sample manipulation, on-chip biosensor integration, and sensitive analyte detection. This research program aims to develop new microfluidic nanobiosensing technologies that integrate two newly emerging nanomaterials - nanofibrillated cellulose (NFC) and molybdenum disulfide (MoS2). The research will focus on design and microfabrication of novel nanobiosensors, on-chip synthesis and integration of functional nanomaterials, investigation of new bioanalytical methods, and optimization and characterization of device performance. The proposed biosensing platforms will inherit the advantages of microfluidic devices and nanomaterial-based biosensors, and thus further advance the state of the art of biosensing technologies. ******This program will lead to innovative nanobiosensing technologies, new theoretical models and design guidelines, and first-of-their-kinds nanobiosensor prototypes suitable for practical applications. These high-performance biosensing platforms will find immediate applications in medical diagnosis and water/food testing, thus benefiting the health and economy of Canadian society. This program will also provide interdisciplinary training for 17 highly qualified personnel (4 Ph.D. students, 3 master's students, and 10 undergraduate students) and equip them with academic and professional skills required to apply the gained knowledge for long-term impact and lead new initiatives in microfluidics and biosensing.