Improving signal to Noise Ratio and decoupling surface and bulk effects in Nicoya's Open surface Plasmin Resonance (SPR) systems

目前的应用程序汇集了Nicoya Life Sciences，位于滑铁卢/基奇纳地区的表面等离子体共振（SPR）** 传感系统的原始制造商，以及多伦多大学（UofT）的Mo Mojahedis教授团队。**Mojahedi教授领导着一个国际知名的小组，在光学/等离子体传感 ** 模式的设计和表征方面拥有专业知识。当前项目的目标是：（a）提高现有和下一代Nicoyas**SPR系统的信噪比（S/N）。(b)在Nicoyas下一代SPR系统的设计 ** 中引入Mojahedis集团开发的多模光谱技术。增加的信噪比将使Nicoya能够通过多种因素提高其系统分辨率（在传感器输出端可以检测到的最小 ** 输入变化量），而多模光谱 ** 将为Nicoya提供前所未有的解耦和消除干扰表面和体积效应的能力。上述 ** 干扰表面和体积效应在任何亲和传感器的操作过程中都存在，它们的存在 ** 不利于准确测定分析物浓度。**成功实施本提案中描述的目标和具体目标将为Nicoya提供更先进的 ** 系统;从而使Nicoya能够在当前市场上更有效地竞争，提高其收入和出口机会，** 在安大略创造许多额外的就业机会，并通过与UofT团队合作为新员工提供培训机会。

The current application brings together Nicoya Life Sciences, an original manufacturer of Surface Plasmon Resonance (SPR)**sensing systems located at Waterloo/Kitchener area, and Prof. Mo Mojahedis team at the University of Toronto (UofT). Professor**Mojahedi leads an internationally renowned group with expertise in design and characterization of optical/plasmonic sensing**modalities.**The goals of the current project are: (a) to improve the signal to noise ratio (S/N) of the existing and next generation Nicoyas**SPR systems. (b) To introduce a technology developed by Mojahedis group known as multimode spectroscopy in the design**of Nicoyas next generation SPR systems. The increased S/N will allow Nicoya to improve its systems resolution (the smallest**amount of change in the input that can be detected at the sensors output) by multiple factors, while the multimode spectroscopy**will provide Nicoya with unprecedented ability to decouple and remove the interfering surface and bulk effects. The**aforementioned interfering surface and bulk effects are present during operation of any affinity sensor and their presence is**detrimental to accurate determination of analyte concentrations.**Successful implementation of the objectives and Specific Aims described in this proposal will provide Nicoya with more advanced**systems; hence enabling Nicoya to compete more effectively in the current market, enhance its revenues and export opportunities,**create many additional jobs in Ontario, and provide a training opportunity for new hires via collaborating with the UofT team.**