Sperm Olympics: Selecting 1 in 100,000 for Intracytoplasmic Sperm Injection

在北美，六分之一的夫妇患有不孕症——自1992年以来增加了两倍。**辅助生殖技术（ARTs），如体外受精（IVF）和胞浆内单精子注射（ICSI），在单精子ICSI的情况下，需要人工干预来手动选择精子**。这种人工过程成本高，效率低，容易出现操作失误，而且很大程度上是随机的，导致妊娠结果不理想，最终影响后代的健康。没有任何精子选择方法能够满足这一不断增长的市场和医疗需求。2015年，我们发现了一种独特的游泳模式，人类精子使用这种模式来导航女性生殖道狭窄的粘性区域。我们已经组建了一个由**男性生育，微流体工程和临床专家组成的团队，开发和临床测试**微流体平台，利用这种天然的游泳能力来选择最高质量的**精子细胞进行直接注射-精子奥运会。

In North America, one in six couples experiences infertility - a 2-fold increase since 1992.**Assisted reproductive technologies (ARTs), such as in vitro fertilization (IVF) and**intracytoplasmic sperm injection (ICSI), require human intervention to manually select sperm** in the case of ICSI a single sperm. This manual process is expensive, inefficient, prone to**operator-error and largely random, resulting in sub-optimal pregnancy outcomes and**ultimately the health of offspring. No sperm selection method addresses this growing market**and medical need. In 2015 we discovered a distinct swimming mode that human sperm use to**navigate confined viscous regions of the female reproductive tract. We have formed a team of**male fertility, microfluidic engineering, and clinical experts to develop and clinically test a**microfluidic platform that leverages this natural swimming ability to select the highest quality**sperm cells for direct injection - the Sperm Olympics.