Analytical methods to enhance manufacturability of latex elastrator rings

为了跟上人类与动物不断变化的关系，需要新的策略来控制阉割牛的疼痛。对年轻的公牛进行阉割的一种常见方法是在动物的阴囊周围系上一条小橡皮筋(称为弹力环)。这会切断血液供应，最终导致睾丸丧失。然而，与其他去势方法一样，使用弹性环必然会给动物带来一些疼痛和不适。预计监管环境的变化-很快将要求在去势期间采用疼痛缓解策略-奇努克合同研究(CCR)正在开发对预装麻醉剂利多卡因的弹力环的厌恶。这种药物已经被批准用于食品类动物，起效时间短，将在去势过程中提供有效的止痛。继与Wulff研究小组成功地建立了Engage合作伙伴关系，优化药物加载程序，并开发量化药物加载和跟踪药物释放的分析方法后，CCR现在正寻求通过一项旨在提高其商业产品可制造性的Engage Plus项目来扩大合作。在该项目期间取得的进展将使CCR能够满足即将到来的申请截止日期，并在价值330亿美元的加拿大养牛业发挥越来越大的作用。

New strategies are required to control pain in cattle undergoing castration, in order to keep abreast of mankind'schanging relationships with animals.A common method to effect castration of young bulls is to attach a small elastic band (called an elastrator ring)around the animal's scrotum. This cuts off blood supply, which eventually leads to the loss of the testicles. Aswith other methods of castration however, application of elastrator rings necessarily causes some pain anddiscomfort to the animal. In anticipation of the changing regulatory landscape - which will soon mandate thatpain mitigation strategies be employed during castration - Chinook Contract Research (CCR) is developing aversion of elastrator rings that come pre-loaded with the anesthetic lidocaine. This drug is already approved foruse in food-producing animals, and has a fast onset time that will provide effective pain relief during thecastration procedure.Following a successful Engage partnership with the Wulff research group to optimize the drug-loadingprocedure, and develop analytical methods to quantify drug loading and follow drug release, CCR is nowseeking to expand their collaboration through an Engage Plus project aimed at enhancing the manufacturabilityof their commercial product. Advances made during this project will allow CCR to meet upcoming filingdeadlines and play an increasing role in the $33 billion Canadian cattle sector.