Caractérisation des polyamines de la laitance de hareng et validation des propriétés bioactives sur culture cellulaire

海洋营养科学公司开发了一种工艺，可以从渔业废物--鲱鱼鱼米--中水解和提取活性生物成分。这些成分可能含有丰富的多胺，已被证明对哺乳动物的心脏保护和衰老预防以及植物的压力管理具有积极作用。因此，鲱鱼乳蛋白水解物有新的市场机会。这些产品价值的实现可能不仅有助于发展一个新的行业，而且还可以通过赋予废品价值来解决环境问题。即使这些水解物已经售出，新的和坚实的科学指控肯定会给扩大市场带来机会。因此，我们计划1)量化ONS从鲱鱼奶水解中产生的三种成分的多胺含量，以及2)测量特定的健康指标(心血管保护和衰老过程)，不同公认的生物化学和分子标记在细胞模型上。我们将特别关注(但不是完全)氧化应激和衰老过程。这些分析将对英国国家统计局提供的两种成分(最容易生产的一种和多胺含量最高的一种)进行。记录国家统计局成分的生物活性肯定会增加价值，并允许新的市场开发。我们还将评估相同的两种成分对模式植物“拟南芥”压力管理的影响。植物将暴露在渗透胁迫和氢气胁迫下。有机海洋希望通过提供已被证明可以减弱压力反应的成分，为园艺和农业行业开发一种利基市场产品，以防止压力影响。

The company Ocean NutraSciences developed a process to hydrolyses and extract active bio-ingredients from a waste product of fishery industry: herring milt. These ingredients are potentially rich in polyamines which have been shown to be active for heart protection and aging prevention in mammals, as well as for stress management in plants. There are therefore new market opportunities for herring milt hydrolysates. These implementations of the value of the products might not only help to develop a new industry, but also to fix an environmental problem by giving value to waste product. Even if these hydrolysates are already sold, new and solid scientific allegations will definitely give opportunities to expand the market. We are therefore planning to 1) Quantify the polyamins content of the three ingredients produced by ONS from herring milt hydrolysis and 2) Measure on specific health targets (cardio-vascular protection and aging process), different acknowledge biochemical and molecular markers on cellular models. We will particularly focus (but not exclusively) on oxidative stress and aging process. These analyses will be performed for two ingredients provided by ONS (the easiest one to produce and the one with highest content of polyamines). Documenting the biological activity of ONS's ingredients will definitely add value and allow new market development. We will also 3) Estimate the impact of the same two ingredients on stress managements in a model plant "arabidopsis". The plant will be exposed to osmotic and hydric stress. Organic Ocean expect to develop a niche market product for horticulture and agriculture industry to prevent stress impact, by providing ingredients that have been proven to attenuate the stress response.