Sparse integrated computational optical imaging systems

集成计算光学成像（ICOI）是一种非常有前途的方法，它涉及改进的光学硬件和数字处理算法的联合设计，以实现成像性能，例如高分辨率，大视场，高帧率，否则未经修改的系统无法实现。******为了克服带宽限制(空间******光学相干断层扫描（OCT）是许多医疗和工业应用的重要地下成像方式。它的分辨率比超声波高一到两个数量级，在生物组织中的典型成像深度为（~ 2mm）。******1。研制实时亚微米分辨率压缩传感全视场OCT系统***2。显影10倍高NA（放大）显微镜***4。推广我们的OCT系统模拟器，以允许有限宽度光束成像。******我们预计我们提出的研究将产生很大的影响，因为1)我们的新型全视野- OCT系统将允许850微米深度的3D细胞成像细胞，而目前共聚焦显微镜允许的成像深度为100微米；2)在不损失横向分辨率、光功率或物镜工作距离的情况下，扩大高NA（放大倍率）光学显微镜的景深的能力，将对各种科学和工业应用产生强烈的积极影响；3)我们预计所提出的扩展景深显微镜和OCT图像血管斑块实时检测器具有很高的商业化潜力；4)一个实用、准确和快速的OCT系统计算机模拟器的可用性将是一个非常有用的工具，可以实现和/或促进未来设计更高性能的OCT系统。******拟议的研究计划还将为培养成像系统、光学、数据采集、图像处理和高级计算的理论和实践方面的2名博士和2名硕士和5名本科生创造独特的机会。********************************* **

Integrated Computational Optical Imaging (ICOI) is a highly promising approach that involves the joint design of modified optical hardware and digital processing algorithms to achieve imaging performance, e.g., high resolution, large field-of-view, high frame rates, that would otherwise be unattainable by the unmodified system.******To overcome bandwidth limitations (spatial ******Optical coherence tomography (OCT) is an important sub-surface imaging modality for numerous medical ***and industrial applications. It has one to two orders of magnitude higher resolution than ultrasound ***and typical imaging depth of (~ 2 mm) in biological tissue.******1. Develop a real-time submicron-resolution compressed sensing full field OCT system ***2. Develop 10 times) of high NA (magnification) microscope***4. Generalize our OCT system simulator to allow imaging with finite-width light beams.******We anticipate a high impact of our proposed research because 1) our novel full field - OCT system would allow 3D cell imaging cells up to a depth of 850 µ m compared to the 100 µ m imaging depth currently allowed by confocal microscopy; 2) the ability to extend the depth-of-field of high NA (magnification) optical microscopes, without loss of lateral resolution, optical power, or objective's working distance, would have a strong positive impact on a wide variety of scientific and industrial applications; 3) we anticipate a high potential for commercialization for the proposed extended depth-of-field microscopy and the proposed real-time detector of vascular plaque w from OCT images; 4) the availability of a practical, accurate and fast computer simulator of OCT systems would be an extremely useful tool to enable and/or facilitate future design of higher performance OCT systems. ******The proposed research program will also create unique opportunities to train 2 Ph.D. and 2 M.Sc. and 5 undergraduate students in both theoretical and practical aspects of Imaging Systems, Optics, Data Acquisition, Image Processing and Advanced Computing.********************************* **