Design of Mechatronics Systems

我的研究计划的全球背景一直是，并将在未来几年内，设计机电系统，在接下来的5年里，我将专注于液体呼吸机的控制。*完全液体通风(TLV)包括用可呼吸的全氟化碳液体(PFC)完全填充肺部，并使用专用液体呼吸机将液体输送到肺部和从肺部移出。最终目标是为所有年龄段(新生儿、婴儿和成人)开发液体呼吸机，并在医院和救护车中引入TLV以进行不同的治疗。总之，液体呼吸机将为新生儿提供有效的肺冲洗，为严重急性呼吸窘迫患者提供卓越的呼吸支持，并通过快速诱导低体温为中风幸存者提供神经保护效果。*TLV控制和监测策略的发展意味着对PFC填充肺中基本流体-结构相互作用的完美理解，因为TLV的基本原理是完全消除空气-肺界面。充填PFC的肺中流体-结构相互作用的这种改变为患者提供了治疗优势，但也造成了呼吸道的基本流动限制(气管可能不稳定和塌陷)，PFC在肺中的流变学行为在很大程度上尚不清楚。*学生博士1-3年级的目标是开发实时监测策略(如肺泡压力、呼吸力学等)。基于PFC在肺中复杂流变性的模型。学生MScA1(1-2年级)的目标是对PFC填充的呼吸道中的流量限制非线性过程进行建模，以便比较实际的流量控制策略。PHD3(3-5岁)的目标是为不确定的肺模型(相对于成人体重、动物模型或人类、是否患有肺部疾病、常温或低温)优化流量控制策略。所有开发的算法和控制策略将通过体外和体内动物实验来实施和评估。*开发的监控策略将向临床医生提供有关肺部疾病演变的信息，例如在肺灌洗期间部分阻塞的呼吸道的状态。实际和优化的控制策略的优缺点将非常有助于临床医生确保有效和安全的TLV。*除了它承诺的研究见解(与TLV相关的出版物)外，该计划还将提出将影响其他领域的振动模型和控制方法的开发。*由于该计划将支持平行的临床前研究，以准备第一个人类先导研究，它将为重大医学突破做出贡献。这项第一项可行性研究在医疗领域的影响将突出液体呼吸机。*

The global context of my research program has been, and will be for the coming years, in the design of mechatronic systems, and for the next 5 years I will focus on the control of liquid ventilator.****Total liquid ventilation (TLV) consists in completely filling the lungs with a breathable perfluorocarbon liquid (PFC) and using a dedicated liquid ventilator to move the liquid into and from the lungs. The ultimate objective is to develop liquid ventilators for all ages (newborns, infants and adults) and introduce TLV in hospitals and ambulances for different therapeutic treatments. In fine, the liquid ventilator will provide an efficient lung lavage for newborns, a superior respiratory support for patients in severe acute respiratory distress, and neuroprotective effects by fast induction of hypothermia for stroke survivors.****The development of control and monitoring strategies in TLV implies a perfect understanding of fundamental fluid-structure interactions in PFC-filled lungs, since the fundamental principle of TLV is the total elimination of the air-lung interface. Such alteration of the fluid-structure interaction in PFC-filled lungs provides therapeutic advantages for patients, but also creates fundamental flow limitations in the airways (the trachea can be unstable and collapse) and the rheological behavior of PFC in the lungs is largely unknown.****The objective of student PhD1 (years 1-3) is to develop real-time monitoring strategies (e.g. alveolar pressure, respiratory mechanics, etc.) based on models of the complicated rheological behavior of PFC in the lungs. The objective of student MScA1 (years 1-2) is to model the flow limitation non-linear process in PFC-filled airways in order to compare the actual flow control strategies. The objective of PhD3 (years 3-5) is to optimize the flow control strategies for uncertain lung models (relative to adult weight, animal models or humans, with or without lung diseases, normothermia or hypothermia). All developed algorithms and control strategies will be implemented and assessed by in-vitro and in-vivo animal experiments.****The developed monitoring strategies will inform the clinician regarding lung disease evolution such as the state of the partially obstructed airways during lung lavage. The advantages/drawback of the actual and optimized control strategies will be very helpful to clinicians to ensure efficient and safe TLV.****In addition to the research insights it promises (publications related to TLV), this program will propose the development of vibration model and control methods that will impact other domains.****Since this program will be performed to support parallel pre-clinical research to prepare the first human pilot study, it will contribute in a major medical breakthrough. The impact in the medical field of this first feasibility study will be such that it will highlight the liquid ventilator.***