Development of expanded applications of NuPET

通过NSERC的一系列合作资助，Cubresa公司一直在与申请人合作开发临床前成像技术，利用硅光电增压器（SiPM）进行正电子发射断层扫描（PET）成像，利用PET友好射频（RF）线圈进行小动物的磁共振成像（MRI）。迄今为止，我们的合作在curesa成为第一个将商业化sipm为基础的临床前PET产品推向市场的过程中发挥了直接作用，该产品被放置在直径为11.5厘米的20厘米MRI磁铁中，可以同时提供PET和MR大鼠图像。鉴于这一成功，古巴现在希望扩大与申请人的研究伙伴关系。拟议的计划是一个双管齐下的项目，包括a)开发技术，使PET图像与功能性MRI图像同时提供大脑的分子图像；B)开发高分辨率MRI成像技术，进一步提高PET图像的量化。在每种情况下，成功开发这些技术是Cubresa整体产品应用开发路线图的关键，因为每种技术都将展示科学可信的结果，但更重要的是，从公司的角度来看，它们将展示同步PET/MRI的重要应用，这是一种必要的营销工具。Cubresa的目标是成为第一个将商用临床前产品推向市场，说明同时PET/MRI的显着优势。这种伙伴关系将使该实验室继续发展其在该领域的专业知识和能力，同时提供与工业市场相关的成像研究HQP培训。

Funded through a series of NSERC partnership grants, Cubresa Inc. have been working with the applicants to develop technologies for pre-clinical imaging that utilize Silicon Photomultipliers (SiPM) for positron emission tomography (PET) imaging and PET friendly radiofrequency (RF) coils for magnetic resonance imaging (MRI) of small animals. To date, our collaboration has played a direct role in Cubresa being the first to market with a commercial SiPM-based pre-clinical PET product which when placed inside a 20cm MRI magnet equipped with an 11.5 cm diameter gradient can provide both PET and MR rat images simultaneously. Given this success, Cubresa now wishes to expand its research partnership with the applicants. The proposed plan is a two pronged project that involves A) development of techniques which will allow PET images to provide molecular images of the brain simultaneously with functional MRI images and B) developing high resolution MRI imaging techniques to improve quantification of PET images further. In each case, success in developing these technologies is key to Cubresa's overall product application development roadmap because each will demonstrate scientifically credible results but more importantly from the company standpoint they will demonstrate important applications of simultaneous PET/MRI, a necessary marketing tool. Cubresa aims to be the first to market with a commercial pre-clinical product illustrating the significant advantages of simultaneous PET/MRI. This partnership will allow the lab to continue to grow its expertise and capacity in this field, while providing HQP training in imaging research that is relevant to the industrial market.