Modeling and Evaluating Pulmonary Ventilation/Perfusion Mismatch

本CRD的主要目的是建立一个数学模型来评估肺部气体通气和肺内气血灌注的不匹配。与我们的工业合作伙伴Rostrum Medical Innovations Inc.（加拿大温哥华）合作，我们的目标是回答以下问题：(i)我们是否可以使用可测量的吸入和呼出气体分数来测量肺内分流（缺乏通气）？（ii）我们能否识别肺死腔（无气血灌注区域）和/或缺乏通气引起的气体通气和气血灌注不匹配的差异？（iii）出现呼吸窘迫，如严重肺泡塌陷或肺水肿时，在同时调节呼吸机和呼气末正压的情况下，血气水平和组织损伤有什么变化？我们的长期目标是为Rostrum提供与数据分析和定量建模相关的关键工具和见解，这是他们业务战略的核心。由此产生的影响是一个更健康的加拿大，并对加拿大经济产生积极影响。

The main objective of this CRD is to develop a mathematical model to evaluate the mismatch of pulmonary gas ventilation and gas-blood perfusion in the lungs. Working with Rostrum Medical Innovations Inc. (Vancouver, Canada), our industrial partner, we aim to answer the following questions: (i) Can we derive a measurement of the intrapulmonary shunt (lack of ventilation) of a lung using measurable inhaled and exhaled gas fractions? (ii) Can we identify differences in gas ventilation and gas-blood perfusion mismatch induced by dead space (areas of no gas-blood perfusion) and/or lack of ventilation in the lung? (iii) In the presence of respiratory distress, such as severe alveoli collapse or pulmonary edema, what happens to blood gas levels and tissue damage under the simultaneous adjustment of the ventilator and positive end-expiratory pressure? Our long term goal is to provide Rostrum with key tools and insights related to data analytics and quantitative modelling that are central to their business strategy. The resulting impact is a healthier Canada and a positive impact on the Canadian economy.