Vapor Drug Delivery System

我们正在申请购买蒸汽管理系统和相关设备（即渗透压计，工作站），以加强我的NSERC资助的发现奖的创新。所要求的设备将在维多利亚大学建立一个新的研究能力，研究使用蒸发方法给药化合物，也将是不列颠哥伦比亚省第一个专门研究这种类型的蒸汽给药的单位。科视Christie实验室为高素质人员（HQP）提供了独特的培训机会，包括复杂的体外电生理学、免疫组织化学和行为技术。这些仪器对于以精确和受控的方式通过吸入输送药物至关重要。渗透压计还将增强进行体内或体外电生理学研究的能力，因为任何年龄的动物都可以在其饲养笼中给予药理学化合物，而不会出现注射应激。该技术也特别适合于在断奶前向老年动物、妊娠母鼠和/或幼仔施用化合物。这些资源将主要用于科视Christie实验室，支持3名博士后研究员，7名研究生和4名本科荣誉学生的培训。这些仪器还将有利于医学科学系所有其他实验室以及维多利亚大学几个相关系的实验室的实验工作（即化学，生物化学，生物学），并使世界各地的合作数量（即不列颠哥伦比亚省大学、圣地亚哥州立大学、休斯顿大学、西班牙巴斯克地区大学等）。这些仪器还将有助于吸引与工业界的新的合作努力，因为化合物的蒸汽管理正在成为一项重要的商业企业。这些仪器将主要支持神经科学的基础研究，尽管它们也将被生物化学，生物学，海洋生物学，癌症生物学和UVic生物医学研究中心的个人使用。

We are applying to purchase a vapor administration system and associated equipment (i.e. osmometer, work station) to enhance innovation in my NSERC funded Discovery award. The requested equipment will establish a new research capacity, for studying the administration of compounds using vaporization methods, at the University of Victoria, and will also be the first unit devoted to research that involves this type of vapor administration in British Columbia.***The Christie laboratory provides unique training opportunities for Highly Qualified Personnel (HQP) in sophisticated in vitro electrophysiology, immunohistochemistry and behavioural techniques. These instruments are essential for the delivery of drugs via inhalation in a precise and controlled fashion. The osmometer will also enhance the capacity for performing studies with either in vivo or in vitro electrophysiology as animals of any age can be administered pharmacological compounds, without injection stress, in their home cages. The technology is also particularly ideal for administering compounds to aged animals, pregnant dams, and/or pups prior to weaning. These resources will be primarily used by the Christie laboratory, supporting the training of 3 postdoctoral fellows, 7 graduate students and 4 undergraduate honors students. The instruments will also benefit the experimental work in all of the other laboratories at the Division of Medical Science, as well as laboratories in several associated departments at the University of Victoria (i.e. Chemistry, Biochemistry, Biology), and enable a number of collaborations worldwide (i.e. University of British Columbia, San Diego State University, University of Houston, University of the Basque Country in Spain, etc.). The instruments will also help attract new collaborative efforts with industry, as vapor administration of compounds is becoming a significant commercial enterprise. These instruments will primarily support basic research in neuroscience, though they will also be used by individuals in biochemistry, biology, marine biology, cancer biology, and the Center for Biomedical Research at UVic.**