Advanced Microfluidic Nanobiosensing

不断改进当前分析平台的需求（例如，在更低的成本、更高的性能和更好的可达性方面）需要开发新的生物传感技术用于诸如分子诊断、环境监测和食品测试的应用。微流体和芯片实验室技术具有创建强大的生物传感平台的巨大潜力，因为它们具有独特的功能，如并行样品操作，芯片上的生物传感器集成和灵敏的分析物检测。该研究计划旨在开发新的微流体纳米生物传感技术，该技术集成了两种新兴的纳米材料-纳米原纤化纤维素（NFC）和二硫化钼（MoS 2）。该研究将集中在新型纳米生物传感器的设计和微制造，功能纳米材料的芯片合成和集成，新的生物分析方法的研究，以及设备性能的优化和表征。所提出的生物传感平台将继承微流体装置和基于纳米材料的生物传感器的优点，从而进一步推进生物传感技术的发展。 该计划将导致创新的纳米生物传感技术，新的理论模型和设计指南，以及适合实际应用的第一种纳米生物传感器原型。 这些高性能的生物传感平台将立即应用于医疗诊断和水/食品检测，从而有利于加拿大社会的健康和经济。 该计划还将为17名高素质人员（4名博士）提供跨学科培训。学生，3名硕士生，10名本科生），并为他们提供所需的学术和专业技能，以应用所获得的知识产生长期影响，并领导微流体和生物传感的新举措。

The demands for continuously improving current analytical platforms (e.g., in terms of lower cost, higher performance, and better accessibility) require new biosensing technologies to be developed for applications such as molecular diagnosis, environmental monitoring, and food testing. Microfluidic and lab-on-a-chip technologies hold great promise for creating powerful biosensing platforms because of their unique capabilities such as parallel sample manipulation, on-chip biosensor integration, and sensitive analyte detection. This research program aims to develop new microfluidic nanobiosensing technologies that integrate two newly emerging nanomaterials - nanofibrillated cellulose (NFC) and molybdenum disulfide (MoS2). The research will focus on design and microfabrication of novel nanobiosensors, on-chip synthesis and integration of functional nanomaterials, investigation of new bioanalytical methods, and optimization and characterization of device performance. The proposed biosensing platforms will inherit the advantages of microfluidic devices and nanomaterial-based biosensors, and thus further advance the state of the art of biosensing technologies. This program will lead to innovative nanobiosensing technologies, new theoretical models and design guidelines, and first-of-their-kinds nanobiosensor prototypes suitable for practical applications. These high-performance biosensing platforms will find immediate applications in medical diagnosis and water/food testing, thus benefiting the health and economy of Canadian society. This program will also provide interdisciplinary training for 17 highly qualified personnel (4 Ph.D. students, 3 master's students, and 10 undergraduate students) and equip them with academic and professional skills required to apply the gained knowledge for long-term impact and lead new initiatives in microfluidics and biosensing.