Sparse integrated computational optical imaging systems

集成计算光学成像(ICOI)是一种非常有前途的方法，它涉及到改进的光学硬件和数字处理算法的联合设计，以实现高分辨率、大视场、高帧频的成像性能，否则，未经修改的系统无法达到这些性能。 要克服带宽限制(空间 光学相干层析成像(OCT)是一种重要的亚表面成像手段 和工业应用。它的分辨率比超声波高一到两个数量级 生物组织的典型成像深度为~2 mm。 1.研制了实时亚微米级压缩传感全场OCT系统 2.将高NA(放大倍率)显微镜显影10倍 4.推广我们的OCT系统模拟器，允许使用有限宽度光束成像。 我们预计我们提出的研究将产生很大的影响，因为1)我们的新型全场OCT系统将允许3D细胞成像细胞的深度达到850微米，而目前共焦显微镜允许的成像深度为100微米；2)在不损失横向分辨率、光学功率或物镜工作距离的情况下，扩展高NA(放大)光学显微镜的景深的能力将对广泛的科学和工业应用产生强烈的积极影响；3)我们预计所提出的扩展景深显微镜和所提出的从OCT图像中实时检测血管斑块的商业化潜力很高；4)实用、准确和快速的OCT系统计算机模拟器的可用性将是实现和/或促进未来更高性能OCT系统设计的一个非常有用的工具。 拟议的研究计划还将创造独特的机会，培养两名博士和两名硕士。以及成像系统、光学、数据采集、图像处理和高级计算理论和实践方面的5名本科生。

Integrated Computational Optical Imaging (ICOI) is a highly promising approach that involves the joint design of modified optical hardware and digital processing algorithms to achieve imaging performance, e.g., high resolution, large field-of-view, high frame rates, that would otherwise be unattainable by the unmodified system. To overcome bandwidth limitations (spatial Optical coherence tomography (OCT) is an important sub-surface imaging modality for numerous medical and industrial applications. It has one to two orders of magnitude higher resolution than ultrasound and typical imaging depth of (~ 2 mm) in biological tissue. 1. Develop a real-time submicron-resolution compressed sensing full field OCT system 2. Develop 10 times) of high NA (magnification) microscope 4. Generalize our OCT system simulator to allow imaging with finite-width light beams. We anticipate a high impact of our proposed research because 1) our novel full field - OCT system would allow 3D cell imaging cells up to a depth of 850 µ m compared to the 100 µ m imaging depth currently allowed by confocal microscopy; 2) the ability to extend the depth-of-field of high NA (magnification) optical microscopes, without loss of lateral resolution, optical power, or objective's working distance, would have a strong positive impact on a wide variety of scientific and industrial applications; 3) we anticipate a high potential for commercialization for the proposed extended depth-of-field microscopy and the proposed real-time detector of vascular plaque w from OCT images; 4) the availability of a practical, accurate and fast computer simulator of OCT systems would be an extremely useful tool to enable and/or facilitate future design of higher performance OCT systems. The proposed research program will also create unique opportunities to train 2 Ph.D. and 2 M.Sc. and 5 undergraduate students in both theoretical and practical aspects of Imaging Systems, Optics, Data Acquisition, Image Processing and Advanced Computing.