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A Stress Activated Znf281 Signalling Pathway Can be Therapeutically Targeted to Prevent Chemotherapy-Induced Cardiotoxicity

A Stress Activated Znf281 Signalling Pathway Can be Therapeutically Targeted to Prevent Chemotherapy-Induced Cardiotoxicity
应激激活的 Znf281 信号通路可作为治疗靶点预防化疗引起的心脏毒性
批准号:
451325
负责人:
Sutendra Gopinath
金额:
$69.66万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2021
资助国家:
加拿大
项目状态:
未结题
起止时间:
2021-09-01 至 2026-09-01

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中文摘要
翻译
早期癌症诊断和更好的治疗选择显著提高了癌症患者的生存率。然而,这些患者最常见和最严重的不良问题仍然是直接导致心力衰竭的发展
英文摘要
Early cancer diagnosis and better treatment options have significantly increased the survival of cancer patients. However, the most common and severe adverse problem for these patients continues to be the development of heart failure as a direct consequen
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会议论文
Tumor-Secreted Nucleosides Can Promote RbFox1 Degradation and Signalling Pathways Relevant to Dedifferentiation in Cardiomyocytes; A Two-Hit Hypothesis with Implications for Cardiotoxicity
  • 批准号:
    467633
  • 项目类别:
    Operating Grants
  • 资助金额:
    $83.6万
  • 财政年份:
    2022
  • 负责人:
    Sutendra Gopinath
  • 依托单位:
Canada Research Chair - Tier 2
  • 批准号:
    453981
  • 项目类别:
  • 资助金额:
    $43.71万
  • 财政年份:
    2021
  • 负责人:
    Sutendra Gopinath
  • 依托单位:
Activation of Pyruvate Kinase M2 as a Novel Therapy for Chemotherapy-Induced Cardiotoxicity
  • 批准号:
    355953
  • 项目类别:
    Operating Grants
  • 资助金额:
    $58.24万
  • 财政年份:
    2016
  • 负责人:
    Sutendra Gopinath
  • 依托单位:
海外基金