Continuous flow manufacturing process of 1,4-dithiothreitol to meet its increasing demand for disease test kits.

BioVectra Inc.和andr<s:1> B. charette - universit<s:1> de montracal教授之间的合作是加拿大国内生产高质量化合物的里程碑，以满足加拿大日益增长的市场需求。这种做法将减轻加拿大对外国供应商的严重依赖，从而增强加拿大经济和医疗保健系统的能力。具体而言，该合作伙伴关系的目标是在连续流动条件下开发有效的合成路线，以生产和供应1,4-二硫苏糖醇（DTT），以满足全球和加拿大市场快速增长的需求。该试剂通常用作检测的关键成分，特别是在去年需求呈指数级增长的COVID-19检测试剂盒中。使用连续流动技术的最佳合成程序将在连续流动合成中心（CCFS）内开发，该中心是位于montracimal大学的最先进实验室。然后，优化的工艺将有效地转移到BioVectra的连续流大型制造工厂，用于DTT的大规模生产和市场分销。这种合作关系是一个交钥匙解决方案，可以快速、安全、有效地为加拿大市场提供至关重要的数字地面电视。通过这种合作关系，学员将获得解决现实问题的经验，并在多学科知识的基础上进行深思熟虑，这将有助于他们成功进入劳动力市场。

The partnership between BioVectra Inc. and Prof. André B. Charette-Université de Montréal is a milestone towards an in-house Canadian manufacturing of high quality compounds in order to meet an increasing Canadian market demand. This approach will allow to mitigate Canada's heavy reliance on foreign suppliers and hence empower the Canadian economy and health care system. Specifically, the goal of this partnership is to develop an efficient synthetic route under continuous flow conditions to manufacture and supply on demand 1,4-dithiothreitol (DTT) to meet the rapidly expanding needs of the global and Canadian market. This reagent is routinely used as a key component in assays and in particular in COVID-19 testing kits where the demand has increased exponentially in the last year. The optimal synthetic procedure using continuous flow techniques will be develop within the Center for Continuous Flow Synthesis (CCFS), a state of the art laboratory located at Université de Montréal. The optimized process will then be effectively transfer to BioVectra's continuous flow large scale manufacturing facility for mass production and market distribution of DTT. This partnership is a turn-key solution to rapidly, safely and effectively supply the Canadian market with the crucially needed DTT. Through this partnership, trainees will gain experience in solving real world problems and well thought after pluri-disciplinary knowledge that will promote their successful entrance in the work force.