Rechargeable potent antiviral facemasks with a novel quaternized N-chloramine (Lab2Market)

作为防止新冠病毒传播的控制措施，N-95口罩和外科口罩等呼吸器和口罩已经无处不在。然而，COVID-19大流行凸显了目前可用口罩的几个问题。由于现有的口罩设计不能主动杀死SARS-CoV-2，因此在接触被污染的个人防护装备后存在接触传播的风险。已证明SARS-CoV-2可以在各种表面上存活：在N-95口罩上，病毒可存活长达21天。一次性口罩的消费也引起了环境问题，因为它会迅速产生废物。我们提出的解决方案是一种可重复使用的口罩，具有可充电的抗病毒特性，具有多种好处，包括主动杀死SARS-CoV-2，降低处理过程中的污染风险，减少浪费。我们的团队开发了专有的基于n -氯胺的抗菌剂，可以与纺织品共价结合，使其具有自消毒性能。n -氯胺结构与氧化氯结合，氧化氯可以通过直接接触转移到SARS-CoV-2等微生物上，导致快速死亡。通过将纺织品暴露在稀释的家用漂白剂中，可以重新获得抗菌活性。与以前的n -氯胺技术相比，我们的新型n -氯胺技术在结构中添加了两个季铵基团，以实现更有效的氧化氯结合。此外，我们的纺织品在50次洗涤循环中经久耐用，同时保持抗病毒活性。这是一种改进，比市售的抗病毒口罩浸渍抗病毒化合物，在洗涤过程中浸出。我们目前正在开发一种三层口罩，它结合了我们的突破性n -氯胺技术，可以在气流中“捕获和消灭”SARS-CoV-2。我们的n -氯胺将被掺入口罩的外层棉层和静电纺纳米纤维过滤膜，并插入口罩的中间口袋。这种口罩的抗病毒活性可以通过家用漂白剂洗涤来恢复，这是一种可重复使用、有效且环保的口罩替代品，可以替代市场上现有的口罩。

Respirators and face masks such as N-95 respirators and surgical masks have become ubiquitous as a control measure to prevent transmission of SARS-CoV-2. However, the COVID-19 pandemic has highlighted several issues with currently available face masks. Since existing mask designs do not actively kill SARS-CoV-2, there is a risk of contact transmission after touching contaminated PPE. SARS-CoV-2 has been demonstrated to survive on various surfaces: on an N-95 mask the virus persists up to 21 days. Consumption of disposable facemasks also raises environmental concerns due to rapid waste generation. Our proposed solution is a reusable facemask endowed with rechargeable antiviral properties which offers a variety of benefits, including active killing of a SARS-CoV-2, reduced risk of contamination during handling and reduced waste. Our group has developed proprietary N-chloramine based antimicrobials which can be covalently bonded to textiles to endow them with self-disinfecting properties. The N-chloramine structure binds oxidative chlorine, which can transfer to microbes such as SARS-CoV-2 through direct contact to cause rapid death. The antimicrobial activity can be recharged by exposing the textile to dilute household bleach. Our novel N-chloramine technology utilizes two added quaternary ammonium groups in the structure to achieve more efficient binding of oxidative chlorine compared to previous N-chloramine technologies. Furthermore, our textiles are durable to 50 laundering cycles while retaining antiviral activity. This is an improvement over commercially available antiviral facemasks with impregnated antiviral compounds which leach out during washing. We are currently developing a three-layer facemask which incorporates our breakthrough N-chloramine technology to "trap and zap" SARS-CoV-2 in the airstream. Our N-chloramine will be incorporated in both the outer cotton layer of the mask and an electrospun nanofibrous filtration membrane to be inserted into the middle pocket of the mask. The antiviral activity of the mask can be recharged via home laundering with bleach, which creates a reusable, effective and environmentally friendly alternative to the masks available on the market.