Novel surface modification technique for chemically inert polymers for medical and biomedical applications

用于医疗和生物医学应用的化学惰性聚合物的新型表面改性技术

• 批准号: 372048-2009
• 负责人: Liu, Song
• 金额: $ 1.6万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=496711
• 关键词: Novel; surface; modification; technique; chemically

Thermoplastic polymers such as poly(ethylene terephthalate) and polypropylene are flexible, resilient, durable, and resist biological degradation. It is these properties that make such polymers desirable for medical uses such as surgical drapes, sutures, vascular grafts and ligament prostheses. However, the hydrophobic surfaces of these polymers can cause medical complications such as thrombosis when their use brings them in contact with blood, or when they are implanted into the human body. Often certain specific applications, such as surgical drapes, will require specialized functions such as antimicrobial surfaces to decrease the possibility of cross-infection in hospitals. Therefore, surface property engineering to either add functions to the substrate polymers or to improve their biocompatibility becomes an important task in the field of medical textiles, biomaterials and biomedical science. The proposed study will develop a novel non-destructive, effective and efficient modification technique for chemically inert thermoplastic polymers. Polymers with functional groups, such as hydroxyls, will be immobilized onto the surfaces of thermoplastic polymers by the formation of an interpenetrating network. To further engineer the surface property, polymer brush architectures can be attached to the surface using a "grafting from" technique after converting the immobilized functional group into proper co-initiator or initiator. Experimental techniques will be explored for the characterization of the formed interpenetrating network and the results correlated to the immobilization efficiency and surface property of the modified materials. The proposed study will lead to a breakthrough in the science of surface modification of chemically inert polymeric materials, which is essential for their applications as medical textiles, biomaterials, and medical devices. The results of the studies can also be used to provide technical support to industries providing protective equipments, medical devices and biomaterials. The proposed work will lead to the training of highly qualified personnel with interdisciplinary skills in Polymer Chemistry, Analytic Chemistry, Medical Textile and Biomaterial Science.

热塑性聚合物如聚对苯二甲酸乙二醇酯和聚丙烯是柔性的、有弹性的、耐用的，并且抵抗生物降解。正是这些性质使得这类聚合物对于医疗用途如手术单、缝合线、血管移植物和韧带假体是理想的。然而，这些聚合物的疏水表面可能会导致医疗并发症，如血栓形成，当它们的使用使它们与血液接触时，或当它们被植入人体时。通常，某些特定的应用，如手术单，将需要专门的功能，如抗菌表面，以减少医院交叉感染的可能性。因此，通过表面改性来增加基材聚合物的功能或改善其生物相容性，成为医用纺织品、生物材料和生物医学领域的重要任务。该研究将为化学惰性热塑性聚合物开发一种新型的非破坏性，有效和高效的改性技术。具有官能团（如羟基）的聚合物将通过形成互穿网络固定到热塑性聚合物的表面上。为了进一步设计表面性能，在将固定化官能团转化为适当的共引发剂或引发剂后，可以使用“接枝”技术将聚合物刷结构连接到表面。实验技术将探索形成的互穿网络的表征和相关的固定化效率和改性材料的表面性能的结果。这项研究将导致化学惰性聚合物材料表面改性科学的突破，这对于它们作为医用纺织品，生物材料和医疗器械的应用至关重要。研究结果还可用于为提供防护设备、医疗器械和生物材料的行业提供技术支持。拟议的工作将导致高素质的人才与高分子化学，分析化学，医用纺织品和生物材料科学的跨学科技能的培训。