Isoform-specific roles of the histone variant macroH2A1 in memory and Alzheimer's disease
Isoform-specific roles of the histone variant macroH2A1 in memory and Alzheimer's disease
批准号:
472567
负责人:
Zovkic Iva
金额:
$7.29万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2022
资助国家:
加拿大
项目状态:
已结题
起止时间:
2022-09-01 至 2023-09-01
中文摘要
阿尔茨海默病(AD)是一种以进行性记忆衰退为特征的衰弱神经退行性疾病。我们最近发现组蛋白变体是一种新的记忆表观遗传调节剂,有望成为治疗记忆缺陷的靶点。
英文摘要
Alzheimer's disease (AD) is a debilitating neurodegenerative disease characterized by progressive memory decline. We recently identified histone variants as novel epigenetic regulators of memory that are promising therapeutic targets for memory deficits.
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会议论文
Histone variant macroH2A1 as a novel regulator of memory deficits in Alzheimer's disease
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批准号:478226
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项目类别:Operating Grants
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资助金额:$82.2万
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财政年份:2023
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负责人:Zovkic Iva
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依托单位:
Canada Research Chair - Tier 2
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批准号:415406
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项目类别:
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资助金额:$43.71万
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财政年份:2019
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负责人:Zovkic Iva
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依托单位:
Histone variant H2A.Z as a novel therapeutic target for Alzheimer's disease
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批准号:368923
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项目类别:Operating Grants
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资助金额:$69.66万
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财政年份:2017
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负责人:Zovkic Iva
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依托单位:
海外基金