Confection Confusion: Interplay Between Diet, Taste, and Nutrition.

Confection Confusion: Interplay Between Diet, Taste, and Nutrition.
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DOI:
10.1016/j.tem.2020.11.011
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发表时间:
2021-03
期刊:
Trends in endocrinology and metabolism: TEM
影响因子:
--
通讯作者:
Dus M
Dus M
中科院分区:
其他
文献类型:
--
作者:
May CE;Dus M

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尽管遗传会塑造我们的味觉,使我们更喜欢某些食物而不是其他食物,但味觉是可塑的,会随着年龄、疾病状态和营养而变化。几十年来,我们已经知道饮食组成可以影响我们感知食物的方式,但许多问题仍然没有答案,特别是关于化学感觉可塑性对摄食行为的影响。在这里,我们回顾了最近的证据,高营养饮食,特别是高糖饮食,对醋蝇,啮齿动物和人类的甜味的影响,并讨论了有关分子和神经机制和研究重点的开放性问题。我们还考虑了饮食依赖的化学感觉可塑性可能影响食物摄入的方式,并在肥胖和代谢疾病的病因学中发挥作用。了解营养,味觉和喂养之间的相互作用将有助于我们确定食物环境在介导慢性疾病中的作用,并设计更好的公共卫生策略来对抗它。
Although genetics shapes our sense of taste to prefer some foods over others, taste sensation is plastic and changes with age, disease state, and nutrition. We have known for decades that diet composition can influence the way we perceive foods, but many questions remain unanswered, particularly regarding the effects of chemosensory plasticity on feeding behavior. Here, we review recent evidence on the effects of high-nutrient diets, especially high dietary sugar, on sweet taste in vinegar flies, rodents, and humans, and discuss open questions about molecular and neural mechanisms and research priorities. We also consider ways in which diet-dependent chemosensory plasticity may influence food intake and play a role in the etiology of obesity and metabolic disease. Understanding the interplay between nutrition, taste sensation, and feeding will help us define the role of the food environment in mediating chronic disease and design better public health strategies to combat it.
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