Emotion-Related Network Reorganization Following Fish Oil Supplementation in Depressed Bipolar Offspring: An fMRI Graph-Based Connectome Analysis.
Emotion-Related Network Reorganization Following Fish Oil Supplementation in Depressed Bipolar Offspring: An fMRI Graph-Based Connectome Analysis.
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DOI：
10.1016/j.jad.2021.05.086
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发表时间：
2021-09-01
影响因子：
6.6
通讯作者：
McNamara RK
中科院分区：
文献类型：
--
作者：
Li W;Lei D;Tallman MJ;Patino LR;Gong Q;Strawn JR;DelBello MP;McNamara RK
情绪障碍与额边缘结构和功能异常以及omega-3多不饱和脂肪酸（包括二十碳五烯酸（EPA）和二十二碳六烯酸（DHA））的缺乏有关。新出现的证据还表明，富含鱼油的n-3 PUFA可促进皮质可塑性和连通性。本研究采用基于图的连接组分析来探讨n-3 PUFA在无药物抑郁青少年双相情感相关网络组织中的作用。在基线时，将患者（n=53）与健康对照（n=53）进行比较，然后将患者随机分组，接受为期12周的安慰剂或鱼油双盲治疗。在基线和终点，测量红细胞EPA+DHA水平，并在执行具有情绪和中性分心物（CPT-END）的连续表现任务时获得fMRI扫描（4特斯拉）。基于图的分析方法用于描述大规模脑网络组织的拓扑特性。与健康对照组相比，患者红细胞EPA+DHA水平较低（p=0.0001），网络聚类系数较低（p=0.029），整体效率较低（p=0.042），额边缘区节点中心性和连通性强度较低（p<0.05）。与安慰剂相比，补充鱼油12周后，红细胞EPA+DHA水平（p<0.001）、网络聚类系数（p=0.005）、整体（p=0.047）和局部（p=0.023）效率以及节点中心性（p<0.05）均有所提高。鱼油补充持续时间相对较短，样本量相对较小。这些发现提供了初步证据，表明在抑郁高危青年中观察到的情绪相关网络组织异常可能可以通过补充鱼油来改变。
Mood disorders are associated with fronto-limbic structural and functional abnormalities and deficits in omega-3 polyunsaturated fatty acids including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Emerging evidence also suggests that n-3 PUFA, which are enriched in fish oil, promote cortical plasticity and connectivity. The present study performed a graph-based connectome analysis to investigate the role of n-3 PUFA in emotion-related network organization in medication-free depressed adolescent bipolar offspring. At baseline patients (n=53) were compared with healthy controls (n=53), and patients were then randomized to 12-week double-blind treatment with placebo or fish oil. At baseline and endpoint, erythrocyte EPA+DHA levels were measured and fMRI scans (4 Tesla) were obtained while performing a continuous performance task with emotional and neutral distractors (CPT-END). Graph-based analysis was used to characterize topological properties of large-scale brain network organization. Compared with healthy controls, patients exhibited lower erythrocyte EPA+DHA levels (p=0.0001), lower network clustering coefficients (p=0.029), global efficiency (p=0.042), and lower node centrality and connectivity strengths in frontal-limbic regions (p<0.05). Compared with placebo, 12-week fish oil supplementation increased erythrocyte EPA+DHA levels (p<0.001), network clustering coefficient (p=0.005), global (p=0.047) and local (p=0.023) efficiency, and node centralities mainly in temporal regions (p<0.05). The duration of fish oil supplementation was relatively short and the sample size was relatively small. These findings provide preliminary evidence that abnormalities in emotion-related network organization observed in depressed high-risk youth may be amenable to modification through fish oil supplementation.
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