An intrinsic vasopressin system in the olfactory bulb is involved in social recognition.
An intrinsic vasopressin system in the olfactory bulb is involved in social recognition.
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许多肽，当作为化学信使在大脑中释放时，对复杂的行为有强大的影响。最引人注目的是，加压素和催产素，曾经被认为是循环激素，其作用仅限于外周器官，现在已知在大脑中释放，在那里它们在社会行为中起着至关重要的作用。在人类中，这些肽系统的破坏与几种神经行为障碍有关，包括Prader-Willi综合征，情感障碍和强迫症，加压素V1 a受体的多态性与自闭症有关。在这里，我们报告说，大鼠嗅球中含有大量的interneurons表达加压素，阻断加压素的行动在嗅球损害大鼠的社会识别能力，加压素激动剂和拮抗剂可以调节嗅球神经元的信息处理。研究结果表明，社会信息处理的一部分是由一个血管加压素系统固有的嗅觉系统。
Many peptides, when released as chemical messengers within the brain, have powerful influences on complex behaviours. Most strikingly, vasopressin and oxytocin, once thought of as circulating hormones whose actions were confined to peripheral organs, are now known to be released in the brain where they play fundamentally important roles in social behaviours. In humans, disruptions of these peptide systems have been linked to several neurobehavioural disorders, including Prader-Willi syndrome, affective disorders, and obsessive-compulsive disorder, and polymorphisms of the vasopressin V1a receptor have been linked to autism. Here we report that the rat olfactory bulb contains a large population of interneurones which express vasopressin, that blocking the actions of vasopressin in the olfactory bulb impairs the social recognition abilities of rats, and that vasopressin agonists and antagonists can modulate the processing of information by olfactory bulb neurones. The findings indicate that social information is processed in part by a vasopressin system intrinsic to the olfactory system.
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16.2
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