Endocrine disruptors and childhood social impairment.
Endocrine disruptors and childhood social impairment.
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DOI：
10.1016/j.neuro.2010.12.009
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发表时间：
2011-03
期刊：
影响因子：
3.4
通讯作者：
Wolff MS
中科院分区：
文献类型：
--
作者：
Miodovnik A;Engel SM;Zhu C;Ye X;Soorya LV;Silva MJ;Calafat AM;Wolff MS
产前暴露于内分泌干扰物有可能影响早期大脑发育。子宫内的神经发育毒性可能在儿童期后期表现为心理社会缺陷。本研究调查了产前暴露于两种普遍存在的内分泌干扰物，邻苯二甲酸酯和双酚A（BPA），以及青少年内城儿童样本的社会行为。对1998年至2002年参加西奈山儿童环境健康研究的妇女（n = 404）的妊娠晚期尿液进行了邻苯二甲酸酯代谢物和BPA分析。当孩子在7到9岁之间时，母亲和孩子被要求返回进行后续评估。在这次访问中，母亲们完成了社会反应量表（SRS）（n = 137），这是一个定量量表，用于测量一般人群中与自闭症谱系障碍（ASD）相关的社会障碍的严重程度。在校正的一般线性模型中，对数转换的低分子量邻苯二甲酸酯（LMW）代谢产物浓度增加与更大的社会缺陷相关（β = 1.53，95% CI 0.25-2.8）。在各分量表中，LMWP还与较差的社会认知（β = 1.40，95% CI 0.1-2.7）、社会沟通（β = 1.86，95% CI 0.5-3.2）和社会意识（β = 1.25，95% CI 0.1-2.4）相关，但与自闭症行为或社会动机无关。未发现与BPA的显著相关性（β = 1.18，95%CI：-0.75，3.11）。在多种族城市人群中，产前邻苯二甲酸酯暴露与儿童期社会损害相关。即使是轻微程度的社会功能受损，在其他健康的个人可以有非常重要的不利影响，在儿童的一生。这些结果扩展了我们先前发现的与产前邻苯二甲酸酯暴露有关的非典型新生儿和幼儿行为。
Prenatal exposure to endocrine disruptors has the potential to impact early brain development. Neurodevelopmental toxicity in utero may manifest as psychosocial deficits later in childhood. This study investigates prenatal exposure to two ubiquitous endocrine disruptors, the phthalate esters and bisphenol A (BPA), and social behavior in a sample of adolescent inner-city children. Third trimester urines of women enrolled in the Mount Sinai Children's Environmental Health Study between 1998 and 2002 (n = 404) were analyzed for phthalate metabolites and BPA. Mother-child pairs were asked to return for a follow-up assessment when the child was between the ages of 7 to 9 years. At this visit, mothers completed the Social Responsiveness Scale (SRS) (n = 137), a quantitative scale for measuring the severity of social impairment related to Autistic Spectrum Disorders (ASD) in the general population. In adjusted general linear models increasing log-transformed low molecular weight phthalate (LMW) metabolite concentrations were associated with greater social deficits (β = 1.53, 95% CI 0.25-2.8). Among the subscales, LMWP were also associated with poorer Social Cognition (β = 1.40, 95% CI 0.1-2.7); Social Communication (β = 1.86, 95% CI 0.5-3.2) and Social Awareness (β = 1.25, 95% CI 0.1-2.4), but not for Autistic Mannerisms or Social Motivation. No significant association with BPA was found (β = 1.18, 95% CI: -0.75, 3.11). Prenatal phthalate exposure was associated with childhood social impairment in a multiethnic urban population. Even mild degrees of impaired social functioning in otherwise healthy individuals can have very important adverse effects over a child's lifetime. These results extend our previous finding of atypical neonatal and early childhood behaviors in relation to prenatal phthalate exposure.
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影响因子：
10.4
作者：
Berkowitz, Gertrud S;Obel, Josephine;Deych, Elena;Lapinski, Robert;Godbold, James;Liu, Zhisong;Landrigan, Philip J;Wolff, Mary S
通讯作者：
Wolff, Mary S
DOI：
10.1097/01.chi.0000046811.95464.21
发表时间：
2003-04-01
影响因子：
13.3
作者：
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通讯作者：
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影响因子：
10.4
作者：
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影响因子：
3.9
作者：
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影响因子：
5.4
作者：
Duty, SM;Silva, MJ;Hauser, R
通讯作者：
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