Heterogeneous dopamine populations project to specific subregions of the primate amygdala.
Heterogeneous dopamine populations project to specific subregions of the primate amygdala.
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DOI：
10.1016/j.neuroscience.2009.11.004
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发表时间：
2010-02-17
期刊：
影响因子：
3.3
通讯作者：
Fudge, J. L.
中科院分区：
文献类型：
--
作者：
Cho, Y. T.;Fudge, J. L.
关键词：
据报道，患有各种精神疾病的患者存在杏仁核功能障碍，而多巴胺对于杏仁核调节恐惧调节的能力至关重要。最近的研究表明，中脑多巴胺能神经元具有异质受体和膜通道特征，以及对离散刺激的不同生理反应。为了开始了解多巴胺如何影响高等灵长类动物的杏仁核生理和病理，我们使用逆行和顺行示踪技术，以及示踪剂和酪氨酸羟化酶（多巴胺标记物）的单和双免疫荧光组织化学，将中脑多巴胺能神经元的输入映射到猴子的各个杏仁核。我们的结果表明，灵长类杏仁核作为一个整体接收广泛的输入，主要来自黑质的背层、致密部和 A8 红后区。来自 A10 腹侧被盖区的输入虽然存在，但不太显着。这些结果与大鼠的数据不同，其中中线 A10 腹侧被盖区是杏仁核“中边缘”通路多巴胺的主要来源。 “固有杏仁核”和“扩展杏仁核”都从黑质背侧层和 A8 红后区接收大部分输入，但扩展杏仁核从腹侧层接收额外的少量输入。此外，“扩展杏仁核”结构比“杏仁核本身”具有更密集的输入，但中央核的外侧核除外，它不接收任何输入。我们的顺行研究证实了这些发现，并揭示了杏仁核本身存在细小的、弥漫性的末端纤维，但在中央核外侧核之外的延伸杏仁核中存在更密集的纤维网络。这些结果表明，A10腹侧被盖区以外的整个背侧层可能调节灵长类动物的杏仁核，并随后成为灵长类动物精神病理学功能障碍的根源。
Amygdala dysfunction has been reported among patients with various psychiatric disorders, and dopamine is critical to the amygdala's ability to mediate fear conditioning. Recent work indicates that the midbrain dopaminergic neurons have heterogeneous receptor and membrane channel profiles, as well as differential physiologic responses to discrete stimuli. To begin understanding how dopamine affects amygdala physiology and pathology in higher primates, we mapped the inputs from the midbrain dopaminergic neurons to various amygdala nuclei in the monkey using retrograde and anterograde tracing techniques, and single and double immunofluorescence histochemistry for tracer and tyrosine hydroxylase, a dopamine marker. Our results show that the primate amygdala as a whole receives broad input, mostly from the dorsal tier of the substantia nigra, pars compacta, and the A8-retrorubral field. Input from the A10-ventral tegmental area, while present, was less prominent. These results differ from data in the rat, where the midline A10-ventral tegmental area is a major source of dopamine to the amygdala “mesolimbic” pathway. Both the “amygdala proper” and the “extended amygdala” receive the majority of their input from the dorsal tier of the substantia nigra and A8-retrorubral field, but the extended amygdala receives additional modest input from the ventral tier. In addition, the “extended amygdala” structures have a denser input than the “amygdala proper,” with the exception of the lateral core of the central nucleus, which receives no input. Our anterograde studies confirm these findings, and revealed fine, diffuse terminal fibers in the amygdala proper, but a denser network of fibers in the extended amygdala outside the lateral core of the central nucleus. These results indicate that the entire extent of the dorsal tier beyond the A10-ventral tegmental area may regulate the amygdala in primates, and subsequently serve as a source of dysfunction in primate psychopathology.
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影响因子：
1.9
作者：
Greba, Q;Kokkinidis, L
通讯作者：
Kokkinidis, L
DOI：
10.1111/j.1749-6632.1988.tb42095.x
发表时间：
1988-10-15
影响因子：
5.2
作者：
DEUTCH, AY;GOLDSTEIN, M;ROTH, RH
通讯作者：
ROTH, RH
DOI：
10.1007/bf00325634
发表时间：
1971-01-01
期刊：
ZEITSCHRIFT FUR ZELLFORSCHUNG UND MIKROSKOPISCHE ANATOMIE
影响因子：
--
作者：
GENESERJENSEN, FA;BLACKSTAD, TW
通讯作者：
BLACKSTAD, TW
影响因子：
2.5
作者：
AGGLETON, JP;MISHKIN, M
通讯作者：
MISHKIN, M
DOI：
10.1111/j.1749-6632.1992.tb24523.x
发表时间：
1992-05-11
影响因子：
5.2
作者：
GERMAN, DC;MANAYE, KF;BROOKS, BA
通讯作者：
BROOKS, BA