A comprehensive mapping of HIV-1 genotypes in various risk groups and regions across China based on a nationwide molecular epidemiologic survey.
A comprehensive mapping of HIV-1 genotypes in various risk groups and regions across China based on a nationwide molecular epidemiologic survey.
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DOI：
10.1371/journal.pone.0047289
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Group for HIV Molecular Epidemiologic Survey
中科院分区：
文献类型：
--
作者：
He X;Xing H;Ruan Y;Hong K;Cheng C;Hu Y;Xin R;Wei J;Feng Y;Hsi JH;Takebe Y;Shao Y;Group for HIV Molecular Epidemiologic Survey
中国正在经历艾滋病毒/艾滋病流行的动态。虽然以血清学为基础的监测系统报告了艾滋病毒/艾滋病的传播情况，但如果不在分子一级绘制地图，就不可能详细跟踪艾滋病毒/艾滋病在人口和区域中的传播情况。因此，我们在全国范围内进行了分子流行病学调查。从2006年新诊断的1 408名艾滋病毒阳性者中确定了艾滋病毒1型。每个基因型的患病率估计加权基因型的患病率从每个省和特定风险的亚群与报告的病例数在相应的亚群在该年。CRF07_BC（35.5%）、CRF01_AE（27.6%）、CRF08_BC（20.1%）和B'亚型（9.6%）是我国HIV-1的4种主要毒株。CRF 07_BC和CRF 08_BC分别是中国东北和东南部注射吸毒者感染的主要驱动因素，而B'亚型在中国中部的前血浆供体中仍占主导地位。相比之下，所有四种毒株在全国异性恋者中的比例都很高，这表明HIV-1流行病从高危人群扩展到了普通人群。CRF01_AE还取代了亚型B，成为男男性行为者感染的主要驱动因素。我们的研究提供了关于中国艾滋病毒/艾滋病流行的多样性和特征的第一个全面的基线数据，反映了独特的区域和风险群体特定的传播动态。研究结果为制定有效的艾滋病毒传播预防措施提供了重要信息。
China is experiencing a dynamic HIV/AIDS epidemic. While serology based surveillance systems have reported the spread of HIV/AIDS, detailed tracking of its transmission in populations and regions is not possible without mapping it at the molecular level. We therefore conducted a nationwide molecular epidemiology survey across the country. HIV-1 genotypes were determined from 1,408 HIV-positive persons newly diagnosed in 2006. The prevalence of each genotype was estimated by weighting the genotype’s prevalence from each province- and risk-specific subpopulation with the number of reported cases in the corresponding subgroups in that year. CRF07_BC (35.5%), CRF01_AE (27.6%), CRF08_BC (20.1%), and subtype B' (9.6%) were the four main HIV-1 strains in China. CRF07_BC and CRF08_BC were the primary drivers of infection among injecting drug users in northeastern and southeastern China, respectively, and subtype B' remained dominant among former plasma donors in central China. In contrast, all four strains occurred in significant proportions among heterosexuals nationwide, pointing to an expansion of the HIV-1 epidemic from high-risk populations into the general population. CRF01_AE also replaced subtype B as the principal driver of infection among men-who-have-sex-with-men. Our study provides the first comprehensive baseline data on the diversity and characteristics of HIV/AIDS epidemic in China, reflecting unique region- and risk group-specific transmission dynamics. The results provide information critical for designing effective prevention measures against HIV transmission.
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中国江苏省男男性行为者中 HIV 和梅毒患病率迅速上升以及 HIV-1 亚型特征
影响因子：
3.1
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影响因子：
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影响因子：
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影响因子：
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影响因子：
5.4
作者：
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通讯作者：
Yu, XF