The serotonin transporter gene and startle response during nicotine deprivation.
The serotonin transporter gene and startle response during nicotine deprivation.
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DOI：
10.1016/j.biopsycho.2010.09.013
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发表时间：
2011-01
影响因子：
2.6
通讯作者：
Cinciripini, Paul M.
中科院分区：
文献类型：
--
作者：
Minnix, Jennifer A.;Robinson, Jason D.;Lam, Cho Y.;Carter, Brian L.;Foreman, Jennifer E.;Vandenbergh, David J.;Tomlinson, Gail E.;Wetter, David W.;Cinciripini, Paul M.
本研究采用情感性惊恐探针方法，研究了尼古丁给药和剥夺对携带至少一个5-羟色胺（5-羟色胺）转运蛋白相关多态性区域（5-羟色胺转运蛋白启动子区域5-HTTLPR） 1 /l基因型个体与5-羟色胺转运蛋白启动子区域（溶质配体载体家族6成员A4 （SLC6A4）或SERT）情绪过程的影响。吸烟者（n = 84）通过尼古丁喷雾（尼古丁vs安慰剂）完成了四个实验阶段。参与者观看情感图片（积极的、消极的、中性的），同时使用声惊吓探针。我们发现，与s/s或s/l基因型的吸烟者相比，l/l基因型的吸烟者在服用尼古丁和安慰剂时对惊吓反应的抑制明显更大。研究结果表明，l/l吸烟者的血清素转运体水平更高，突触血清素清除速度更快，当他们接触尼古丁时，防御系统的激活程度会大幅降低。
Affective startle probe methodology was used to examine the effects of nicotine administration and deprivation on emotional processes among individuals carrying at least one s allele versus those with the l/l genotype of the 5-Hydroxytryptamine (Serotonin) Transporter Linked Polymorphic Region, 5-HTTLPR in the promoter region of the serotonin transporter gene [Solute Ligand Carrier family 6 member A4 (SLC6A4) or SERT]. Smokers (n = 84) completed four laboratory sessions crossing deprivation (12-hour deprived vs. non-deprived) with nicotine spray (nicotine vs. placebo). Participants viewed affective pictures (positive, negative, neutral) while acoustic startle probes were administered. We found that smokers with the l/l genotype showed significantly greater suppression of the startle response when provided with nicotine vs. placebo than those with the s/s or s/l genotypes. The results suggest that l/l smokers, who may have higher levels of the serotonin transporter and more rapid synaptic serotonin clearance, experience substantial reduction in activation of the defensive system when exposed to nicotine.
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影响因子：
4.7
作者：
Cinciripini, Paul M.;Robinson, Jason D.;Wetter, David W.
通讯作者：
Wetter, David W.
DOI：
10.1098/rspb.2008.1788
发表时间：
2009-05-22
期刊：
Proceedings. Biological sciences
影响因子：
--
作者：
Fox E;Ridgewell A;Ashwin C
通讯作者：
Ashwin C
影响因子：
3.1
作者：
FAGERSTROM, KO
通讯作者：
FAGERSTROM, KO
影响因子：
10.6
作者：
Hare, TA;Tottenham, N;Casey, BJ
通讯作者：
Casey, BJ
影响因子：
10.6
作者：
Bertolino, A;Arciero, G;Scarabino, T
通讯作者：
Scarabino, T