Altered spontaneous activity in young chronic cigarette smokers revealed by regional homogeneity.

Altered spontaneous activity in young chronic cigarette smokers revealed by regional homogeneity.
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区域同质性揭示年轻长期吸烟者自发活动的改变

DOI:
10.1186/1744-9081-8-44
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发表时间:
2012-08-22
期刊:
Behavioral and brain functions : BBF
影响因子:
--
通讯作者:
Hao W
Hao W
中科院分区:
其他
文献类型:
--
作者:
Tang J;Liao Y;Deng Q;Liu T;Chen X;Wang X;Xiang X;Chen H;Hao W

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研究背景尽管许多fMRI研究表明慢性吸烟者的任务相关活动模式发生了改变,但很少有关于年轻慢性吸烟者静息状态脑活动的研究发表。(年龄:27.9 ± 5.6岁)和44名健康非吸烟对照者(年龄:26.3 ± 5.8岁)进行功能磁共振成像(fMRI),并进行区域均匀性(ReHo)分析结果与健康对照组相比,吸烟组右侧额叶下部ReHo降低,左侧顶叶上级ReHo升高(P <0.01,35体素,Alphasim校正).结论我们的数据表明,在静息状态下,与非吸烟者相比,慢性吸烟者的右下额叶皮层的神经功能较不同步,而左上级顶叶的神经功能较不同步。右下额叶皮层的同步性降低可能反映了对奖励相关行为缺乏控制,而同步性增加可能反映了吸烟冲动。
BackgroundFew studies have been previously published about the resting state brain activity in young chronic smokers, although many previous fMRI studies have shown that the task-related activity pattern is altered in chronic smokers.MethodsIn the present study, forty-five healthy smokers (age: 27.9 ± 5.6 year) and forty-four healthy non-smoking control subjects (age: 26.3 ± 5.8 year) have been imaged with functional magnetic resonance imaging (fMRI) and analyzed with the regional homogeneity (ReHo) approach.ResultsCompared with healthy controls, decreased ReHo was found in smokers in the right inferior frontal cortex and increased ReHo was found in the left superior parietal lobe (P < 0.01, 35 Voxels,Alphasim corrected).ConclusionsOur data suggested that, during resting state, neural function is less synchronized in the right inferior frontal cortex and more synchronized in the left superior parietal lobe in chronic smokers compared to non-smokers. The decreased synchronization in the right inferior frontal cortex may reflect lacking of control over reward-related behavior, and the increased synchronization may reflect smoking urges.
DOI: 10.1371/journal.pone.0025031
发表时间: 2011
期刊: PloS one
影响因子: 3.7
作者:
Song XW;Dong ZY;Long XY;Li SF;Zuo XN;Zhu CZ;He Y;Yan CG;Zang YF
通讯作者: Zang YF
DOI: 10.1111/j.1369-1600.2011.00359.x
发表时间: 2013-07-01
期刊: ADDICTION BIOLOGY
影响因子: 3.4
作者:
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通讯作者: Lu, Lin
年轻慢性吸烟者的双侧额顶叶完整性:弥散张量成像研究
DOI: 10.1371/journal.pone.0026460
发表时间: 2011
期刊: PloS one
影响因子: 3.7
作者:
Liao Y;Tang J;Deng Q;Deng Y;Luo T;Wang X;Chen H;Liu T;Chen X;Brody AL;Hao W
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DOI: 10.1023/a:1024190429920
发表时间: 2002-03-01
期刊: JOURNAL OF NEUROCYTOLOGY
影响因子: --
作者:
Fuster, JM
通讯作者: Fuster, JM
DOI: 10.1016/j.neubiorev.2010.12.012
发表时间: 2011-04
影响因子: 8.2
作者:
Liu, Xun;Hairston, Jacqueline;Schrier, Madeleine;Fan, Jin
通讯作者: Fan, Jin