Serum selenium and serum lipids in US adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004.
Serum selenium and serum lipids in US adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004.
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DOI：
10.1016/j.atherosclerosis.2010.01.005
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发表时间：
2010-06
期刊：
影响因子：
5.3
通讯作者：
Guallar E
中科院分区：
文献类型：
--
作者：
Laclaustra M;Stranges S;Navas-Acien A;Ordovas JM;Guallar E
高硒最近与几种心血管和代谢危险因素有关，包括糖尿病，血压和血脂水平。我们在2003-2004年国家健康与营养调查（NHANES）中评估了血清硒与空腹血脂水平的相关性，这是最近获得的测量硒水平的美国人群的代表性样本。NHANES 2003-2004年对1159名≥40岁成年人进行的横断面分析。采用电感耦合等离子体动态反应池质谱法测定血清硒。空腹血清总胆固醇，甘油三酯和高密度脂蛋白胆固醇酶测定和低密度脂蛋白胆固醇计算。平均血清硒为136.7 µg/L。多变量调整平均差异（95%置信区间）（≥147 µg/L）降至最低（<124 µg/L）硒的四分位数为18.9总胆固醇为（9.9，28.0）mg/dL，12.7 LDL胆固醇为（3.3，22.2）mg/dL，HDL胆固醇为3.9（0.4，7.5）mg/dL，甘油三酯为11.5（−7.6，30.7）mg/dL。在样条回归模型中，总胆固醇和LDL胆固醇水平随着硒浓度的增加而逐渐增加。HDL胆固醇随着硒的增加而增加，但在血清硒水平高于120 µg/L（第20百分位数）时达到平台。硒与硒的关系呈U型。在美国成年人中，高血清硒浓度与血清总胆固醇和LDL胆固醇浓度升高相关。硒仅在低硒水平下与高密度脂蛋白胆固醇升高相关。鉴于膳食硒摄入量和补充剂的增加趋势，这些关联背后的因果机制需要充分表征。
High selenium has been recently associated with several cardiovascular and metabolic risk factors including diabetes, blood pressure and lipid levels. We evaluated the association of serum selenium with fasting serum lipid levels in the National Health and Nutrition Examination Survey (NHANES) 2003–2004, the most recently available representative sample of the US population that measured selenium levels. Cross-sectional analysis of 1159 adults ≥40 years old from NHANES 2003–2004. Serum selenium was measured by inductively coupled plasma-dynamic reaction cell-mass spectrometry. Fasting serum total-cholesterol, triglycerides, and HDL cholesterol were measured enzymatically and LDL cholesterol was calculated. Mean serum selenium was 136.7 µg/L. The multivariable adjusted average differences (95% confidence interval) comparing the highest (≥147 µg/L) to the lowest (<124 µg/L) selenium quartiles were 18.9 (9.9, 28.0) mg/dL for total cholesterol, 12.7 (3.3, 22.2) mg/dL for LDL cholesterol, 3.9 (0.4, 7.5) mg/dL for HDL cholesterol, and 11.5 (−7.6, 30.7) mg/dL for triglycerides. In spline regression models, total and LDL cholesterol levels increased progressively with increasing selenium concentrations. HDL cholesterol increased with selenium but reached a plateau above 120 µg/L of serum selenium (20th percentile). The triglyceride-selenium relationship was U-shaped. In US adults, high serum selenium concentrations were associated with increased serum concentrations of total and LDL cholesterol. Selenium was associated with increasing HDL cholesterol only at low selenium levels. Given increasing trends in dietary selenium intake and supplementation, the causal mechanisms underlying these associations need to be fully characterized.
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影响因子：
39.2
作者：
Stranges, Saverio;Marshall, James R.;Reid, Mary E.
通讯作者：
Reid, Mary E.
影响因子：
1.9
作者：
Hercberg, S;Bertrais, S;Roussel, AM
通讯作者：
Roussel, AM
DOI：
10.1016/0304-4165(74)90188-3
发表时间：
1974-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
BURK, RF
通讯作者：
BURK, RF
影响因子：
3.9
作者：
Ducros, V;Laporte, F;Favier, A
通讯作者：
Favier, A
影响因子：
5.3
作者：
JOSSA, F;TREVISAN, M;MANCINI, M
通讯作者：
MANCINI, M