Development of urine standard reference materials for metabolites of organic chemicals including polycyclic aromatic hydrocarbons, phthalates, phenols, parabens, and volatile organic compounds.

Development of urine standard reference materials for metabolites of organic chemicals including polycyclic aromatic hydrocarbons, phthalates, phenols, parabens, and volatile organic compounds.
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DOI:
10.1007/s00216-014-8441-0
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发表时间:
2015-04
影响因子:
4.3
通讯作者:
Sjoedin, Andreas
Sjoedin, Andreas
中科院分区:
化学2区
文献类型:
--
作者:
Schantz, Michele M.;Benner, Bruce A., Jr.;Heckert, N. Alan;Sander, Lane C.;Sharpless, Katherine E.;Vander Pol, Stacy S.;Vasquez, Y.;Villegas, M.;Wise, Stephen A.;Alwis, K. Udeni;Blount, Benjamin C.;Calafat, Antonia M.;Li, Zheng;Silva, Manori J.;Ye, Xiaoyun;Gaudreau, Eric;Patterson, Donald G., Jr.;Sjoedin, Andreas

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两种新的标准参考物质(SRM),SRM 3672吸烟者尿液中的有机污染物(冷冻)和SRM 3673非吸烟者尿液中的有机污染物(冷冻),已经开发出来,以支持评估人类暴露于选定的有机环境污染物的研究。三个组织之间的合作产生了11种羟基化多环芳烃(OH-PAH)的认证值和11种邻苯二甲酸酯代谢物、8种环境酚和对羟基苯甲酸酯以及24种挥发性有机化合物(VOC)代谢物的参考值。肌酐和游离形式的咖啡因、可可碱、布洛芬、尼古丁、可替宁和3-羟基可替宁也有参考值。这是第一个尿液标准物质,其特征在于有机环境污染物的代谢物。值得注意的是,两个SRM中的环境有机污染物的质量分数在人口调查研究报告的范围内,如国家健康和营养检查调查(NHANES)和加拿大健康措施调查(CHMS)。这些标准物质将作为质量控制样品,用于确保人口调查研究结果的一致性,并将填补一个空白,以评估监测人类接触这些有机环境污染物的研究中使用的分析方法的准确性。
Two new Standard Reference Materials (SRMs), SRM 3672 Organic Contaminants in Smokers’ Urine (Frozen) and SRM 3673 Organic Contaminants in Non-Smokers’ Urine (Frozen), have been developed in support of studies for assessment of human exposure to select organic environmental contaminants. Collaborations among three organizations resulted in certified values for 11 hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) and reference values for 11 phthalate metabolites, 8 environmental phenols and parabens, and 24 volatile organic compound (VOC) metabolites. Reference values are also available for creatinine and the free forms of caffeine, theobromine, ibuprofen, nicotine, cotinine, and 3-hydroxycotinine. These are the first urine Certified Reference Materials characterized for metabolites of organic environmental contaminants. Noteworthy, the mass fractions of the environmental organic contaminants in the two SRMs are within the ranges reported in population survey studies such as the National Health and Nutrition Examination Survey (NHANES) and the Canadian Health Measures Survey (CHMS). These SRMs will be useful as quality control samples for ensuring compatibility of results among population survey studies and will fill a void to assess the accuracy of analytical methods used in studies monitoring human exposure to these organic environmental contaminants.
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