Platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio associated with disease activity in patients with Takayasu's arteritis: a case-control study.
Platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio associated with disease activity in patients with Takayasu's arteritis: a case-control study.
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DOI：
10.1136/bmjopen-2016-014451
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发表时间：
2017-05-04
期刊：
影响因子：
2.9
通讯作者：
Liao H
中科院分区：
文献类型：
--
作者：
Pan L;Du J;Li T;Liao H
血小板与淋巴细胞比率（PLR）和嗜中性粒细胞与淋巴细胞比率（NLR）已被报道反映各种自身免疫性疾病的炎症反应和疾病活动。本研究旨在评价PLR和NLR作为监测大动脉炎（TAK）疾病活动性的标志物的价值。进行了一项回顾性病例对照研究，涉及88例TAK患者和78例健康对照。我们比较了患者和健康对照者的PLR和NLR，并分析了PLR或NLR与TAK疾病活动指数之间的相关性。在接受TAK治疗的患者中观察到PLR和NLR增加。PLR与hs-C-反应蛋白（hs-CRP）（r=0.239，p=0.010）和红细胞沉降率（ESR）（r=0.270，p=0.010）呈正相关。NLR与Kerr评分（r=0.284，p=0.002）、hs-CRP（r=0.313，p=0.006）和ESR（r=0.249，p=0.019）呈正相关。PLR水平183.39被证明是TAK的预测临界值（灵敏度37.8%，特异性93.0%，曲线下面积（AUC）=0.691）。发现NLR水平2.417是TAK的预测临界值（灵敏度75.6%，特异性55.8%，AUC=0.697）。PLR和NLR可能是反映TAK患者炎症和疾病活动性的有用标志物。
Platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) have been reported to reflect the inflammatory response and disease activity in a variety of autoimmune diseases. This study aimed to evaluate the value of PLR and NLR as markers to monitor disease activity in Takayasu’s arteritis (TAK). A retrospective case–control study involving 88 patients with TAK and 78 healthy controls was performed. We compared the PLR and NLR between patients and healthy controls, and also analysed the correlations between PLR or NLR and indices of TAK disease activity. Increased PLR and NLR were observed in patients with TAK. PLR was positively correlated with hs-C-reactive protein (hs-CRP) (r=0.239, p=0.010) and erythrocyte sedimentation rate (ESR) (r=0.270, p=0.010). NLR also exhibited a positive relationship with Kerr’s score (r=0.284, p=0.002), hs-CRP (r=0.313, p=0.006) and ESR (r=0.249, p=0.019). A PLR level of 183.39 was shown to be the predictive cut-off value for TAK (sensitivity 37.8%, specificity 93.0%, area under the curve (AUC)=0.691). A NLR level of 2.417 was found to be the predictive cut-off value for TAK (sensitivity 75.6%, specificity 55.8%, AUC=0.697). PLR and NLR could be useful markers to reflect inflammation and disease activity in patients with TAK.
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