Antigenicity of structural components from porcine transmissible gastroenteritis virus
Antigenicity of structural components from porcine transmissible gastroenteritis virus
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DOI：
10.1016/0378-1135(79)90034-8
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发表时间：
1979-03
影响因子：
3.3
通讯作者：
Cartwright SF
中科院分区：
文献类型：
--
作者：
Garwes DJ;Lucas MH;Higgins DA;Pike BV;Cartwright SF
妊娠母猪接种灭活的传染性胃肠炎病毒和通过去污剂处理病毒获得的病毒表面突起和亚病毒颗粒制剂。在接受全病毒或表面突起制备物的动物的血清和初乳中证实了中和抗体，而亚病毒颗粒未能刺激中和抗体形成。用全病毒和结构组分接种的兔血清获得了类似的结果。所有三种制剂均刺激凝集抗体的形成，如沉降分析和放射性标记病毒过滤研究所示。检查了通过乳房内途径接种的母猪中负责中和抗体活性的免疫球蛋白类别。在每种情况下，免疫球蛋白类进行了测定，发现IgG。一个母猪接受表面投影也有伊加与中和活性在她的初乳。相反，母猪感染活的全病毒导致IgG、IgM和伊加类的中和抗体。
Pregnant sows were inoculated with inactivated transmissible gastroenteritis virus and with preparations of virus surface projections and subviral particles derived by detergent treatment of the virus. Neutralising antibody was demonstrated in serum and colostrum from animals that received whole virus or preparations of surface projections whereas subviral particles failed to stimulate neutralising antibody formation. Similar results were obtained with serum from rabbits inoculated with whole virus and structural components. All three preparations stimulated the formation of agglutinating antibodies, as demonstrated by sedimentation analysis and filtration studies with radiolabelled virus. The immunoglobulin classes responsible for neutralising antibody activity in sows inoculated by the intramammary route were examined. In each case where the immunoglobulin class was determined, IgG was found. One sow that received surface projections also had IgA with neutralising activity in her colostrum. In contrast, infection of sows with live whole virus resulted in neutralising antibody of the IgG, IgM and IgA classes.
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影响因子：
0.8
作者：
CARTWRIGHT, SF
通讯作者：
CARTWRIGHT, SF
影响因子：
2.4
作者：
HIGGINS, DA
通讯作者：
HIGGINS, DA
影响因子：
3.8
作者：
GARWES, DJ;POCOCK, DH
通讯作者：
POCOCK, DH
影响因子：
3.1
作者：
STONE, SS;KEMENY, LJ;JENSEN, MT
通讯作者：
JENSEN, MT
DOI：
10.1159/000230312
发表时间：
1970-01-01
期刊：
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY
影响因子：
--
作者：
VAERMAN, JP;HEREMANS, JF
通讯作者：
HEREMANS, JF