Theta oscillatory dynamics serving cognitive control index psychosocial distress in youth.
Theta oscillatory dynamics serving cognitive control index psychosocial distress in youth.
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DOI：
10.1016/j.ynstr.2023.100599
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发表时间：
2024-03
影响因子：
5
通讯作者：
Wilson, Tony W.
中科院分区：
文献类型：
--
作者：
Schantell, Mikki;Mansouri, Amirsalar;Arif, Yasra;Rice, Danielle L.;Wang, Yu-Ping;Calhoun, Vince D.;Stephen, Julia M.;Wilson, Tony W.
关键词：
青少年的社会心理困扰是一个重大的公共卫生问题，其特征是认知控制加工过程受到干扰。利用美国国家心理健康研究所的研究领域标准（RDoC）框架，我们对青少年中服务于认知控制的社会心理困扰的多维神经振荡标记进行了量化。
样本包括39名青春期前后的参与者，他们在脑磁图（MEG）检测期间完成了美国国立卫生研究院工具箱情绪量表（NIHTB - EB）和埃里克森侧抑制任务。通过对NIHTB - EB的评估进行探索性因素分析，计算出一个社会心理困扰指数。在时频域对MEG数据进行分析，并从描绘神经认知干扰效应的振荡图中提取峰值体素，用于体素时间序列分析，以确定服务于认知控制的动态过程中作为社会心理困扰函数的自发和振荡异常。此外，我们还量化了社会心理困扰与支持认知控制的区域之间动态功能连接的关系。
连续的社会心理困扰指数与经过验证的儿童精神病理学指标密切相关。在左侧背外侧前额叶皮层（dlPFC）和中扣带皮层（MCC）中发现了θ波段神经认知干扰。对这些区域的时间序列分析表明，社会心理困扰程度越高，dlPFC和MCC的自发活动越强，MCC中的θ振荡越弱。最后，我们发现dlPFC和MCC之间更强的相位相干性与更大的社会心理困扰有关。
更大的社会心理困扰表现为服务于认知控制的自发和振荡θ活动的改变，以及dlPFC和MCC之间的过度连接。
Psychosocial distress among youth is a major public health issue characterized by disruptions in cognitive control processing. Using the National Institute of Mental Health's Research Domain Criteria (RDoC) framework, we quantified multidimensional neural oscillatory markers of psychosocial distress serving cognitive control in youth. The sample consisted of 39 peri-adolescent participants who completed the NIH Toolbox Emotion Battery (NIHTB-EB) and the Eriksen flanker task during magnetoencephalography (MEG). A psychosocial distress index was computed with exploratory factor analysis using assessments from the NIHTB-EB. MEG data were analyzed in the time-frequency domain and peak voxels from oscillatory maps depicting the neural cognitive interference effect were extracted for voxel time series analyses to identify spontaneous and oscillatory aberrations in dynamics serving cognitive control as a function of psychosocial distress. Further, we quantified the relationship between psychosocial distress and dynamic functional connectivity between regions supporting cognitive control. The continuous psychosocial distress index was strongly associated with validated measures of pediatric psychopathology. Theta-band neural cognitive interference was identified in the left dorsolateral prefrontal cortex (dlPFC) and middle cingulate cortex (MCC). Time series analyses of these regions indicated that greater psychosocial distress was associated with elevated spontaneous activity in both the dlPFC and MCC and blunted theta oscillations in the MCC. Finally, we found that stronger phase coherence between the dlPFC and MCC was associated with greater psychosocial distress. Greater psychosocial distress was marked by alterations in spontaneous and oscillatory theta activity serving cognitive control, along with hyperconnectivity between the dlPFC and MCC.
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影响因子：
10.6
作者：
Berman, RM;Cappiello, A;Krystal, JH
通讯作者：
Krystal, JH
影响因子：
4.6
作者：
Perez VB;Ford JM;Roach BJ;Woods SW;McGlashan TH;Srihari VH;Loewy RL;Vinogradov S;Mathalon DH
通讯作者：
Mathalon DH
DOI：
10.1038/nrn4025
发表时间：
2015-10
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Amso D;Scerif G
通讯作者：
Scerif G
影响因子：
4.8
作者：
Casagrande CC;Lew BJ;Taylor BK;Schantell M;O'Neill J;May PE;Swindells S;Wilson TW
通讯作者：
Wilson TW
影响因子：
5.5
作者：
Arif, Yasra;Spooner, Rachel K.;Heinrichs-Graham, Elizabeth;Wilson, Tony W.
通讯作者：
Wilson, Tony W.