Clonal development and organization of the adult Drosophila central brain.
Clonal development and organization of the adult Drosophila central brain.
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DOI：
10.1016/j.cub.2013.02.057
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发表时间：
2013-04-22
期刊：
影响因子：
9.2
通讯作者：
Lee, Tzumin
中科院分区：
文献类型：
--
作者：
Yu, Hung-Hsiang;Awasaki, Takeshi;Schroeder, Mark David;Long, Fuhui;Yang, Jacob S.;He, Yisheng;Ding, Peng;Kao, Jui-Chun;Wu, Gloria Yueh-Yi;Peng, Hanchuan;Myers, Gene;Lee, Tzumin
昆虫的大脑可以分为神经鞘，神经鞘由本地和远程来源的神经突形成。相互联系的复杂性掩盖了这些神经毛发是如何在发育过程中建立和相互联系的。果蝇的中央大脑由固定数量的神经母细胞(NBS)发育而来，这些神经母细胞在区域簇中沉积神经元。通过确定单个NB克隆并将其投射到特定的神经丛中，我们揭开了脑神经网络的区域发展。详尽的克隆分析揭示了95个具有特征性细胞体位置和轴突轨迹的定型神经元谱系。大多数克隆都表现出复杂的投射模式，但尽管复杂，相邻的克隆通常会共同支配相同的局部神经束(S)，并进一步瞄准一组有限的远处神经毛。这些观察结果证明了整个果蝇中央大脑的神经毛和神经束连接的区域克隆发育。
The insect brain can be divided into neuropils that are formed by neurites of both local and remote origin. The complexity of the interconnections obscures how these neuropils are established and interconnected through development. The Drosophila central brain develops from a fixed number of neuroblasts (NBs) that deposit neurons in regional clusters. By determining individual NB clones and pursuing their projections into specific neuropils we unravel the regional development of the brain neural network. Exhaustive clonal analysis revealed 95 stereotyped neuronal lineages with characteristic cell body locations and neurite trajectories. Most clones show complex projection patterns, but despite the complexity, neighboring clones often co-innervate the same local neuropil(s) and further target a restricted set of distant neuropils. These observations argue for regional clonal development of both neuropils and neuropil connectivity throughout the Drosophila central brain.
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