Neural substrates underlying progressive micrographia in Parkinson's disease
Neural substrates underlying progressive micrographia in Parkinson's disease
复制标题
帕金森病进行性小写症的神经基质
DOI：
10.1002/brb3.1669
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发表时间：
2020
影响因子：
3.1
通讯作者：
Suzuki Kyoko
中科院分区：
文献类型：
--
作者：
Kanno Shigenori;Shinohara Mayumi;Kanno Kasumi;Gomi Yukihiro;Uchiyama Makoto;Nishio Yoshiyuki;Baba Toru;Hosokai Yoshiyuki;Takeda Atsushi;Fukuda Hiroshi;Mori Etsuro;Suzuki Kyoko
与显微书写发展相关的神经基质仍不清楚。我们的目的是阐明帕金森病（PD）patients.MethodsForty PD患者和20名健康对照的micrographia的神经基板进行手写测试，涉及自由书写和复制。我们测量了每个字母的大小和静息脑葡萄糖代谢率的PD患者和另一组年龄和性别匹配的14名健康对照（HC），谁没有参加的写作tests.ResultsIn PD患者，使用静息态18 F-氟脱氧葡萄糖正电子发射断层扫描仪，与自由书写相关的一致micrographia（CM）的患病率为2.5%，这两个任务。另外，自由书写和复制的进行性显微书写（PM）患病率分别为15%和17.5%。在PD患者中，这些任务之间的字母大小没有显著差异，而复制的字母大小的变异性与自由书写的字母大小有显著差异。在PD患者中，两项任务中字母大小的平均值和递减与布雷迪/运动功能减退的严重程度无显著相关性。在自由书写方面，与无PM的PD患者相比，PM的PD患者在右侧中扣带回皮质前部（包括头侧扣带回运动区）显示葡萄糖代谢降低。对于复印，PD患者PM显示葡萄糖代谢低下，在右侧上级枕回，包括V3 A，与那些没有PM。结论这些研究结果表明，PM在PD患者自由书写是由监测是否实际的手写运动是可取的，以保持字母大小在自定进度手写的困难。相比之下，PD患者在复印中的PM是由于缺乏关于个人笔迹和手部动作的视觉信息而引起的，这些信息被用作保持字母大小的线索。
IntroductionThe neural substrates associated with the development of micrographia remain unknown. We aimed to elucidate the neural substrates underlying micrographia in Parkinson's disease (PD) patients.MethodsForty PD patients and 20 healthy controls underwent handwriting tests that involved free writing and copying. We measured the size of each letter and the resting cerebral glucose metabolic rate of the PD patients and another group of age‐ and sex‐matched 14 healthy controls (HCs), who had not participated in the writing tests, using resting‐state 18F‐fluorodeoxyglucose positron emission tomography.ResultsIn the PD patients, the prevalence of consistent micrographia (CM) associated with free writing was 2.5% for both tasks. Alternatively, the prevalence of progressive micrographia (PM) was 15% for free writing and 17.5% for copying. In the PD patients, there was no significant difference in the letter sizes between these tasks, whereas the variability of the letter sizes for copying was significantly different from that for free writing. The means and decrements in letter sizes in either task were not significantly correlated with the severity of brady/hypokinesia in the PD patients. For free writing, the PD patients with PM showed glucose hypometabolism in the anterior part of the right middle cingulate cortex, including the rostral cingulate motor area, compared with those without PM. For copying, the PD patients with PM showed glucose hypometabolism in the right superior occipital gyrus, including V3A, compared with those without PM.ConclusionsThese findings suggest that PM in free writing in PD patients is caused by the difficulty of monitoring whether the actual handwriting movements are desirable for maintaining letter size during self‐paced handwriting. By contrast, PM in copying in PD patients is evoked by a lack of visual information about the personal handwriting and hand motions that are used as cues for maintaining letter sizes.
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影响因子：
2.5
作者：
SHIMA, K;AYA, K;TANJI, J
通讯作者：
TANJI, J
影响因子：
2.5
作者：
MATSUZAKA, Y;AIZAWA, H;TANJI, J
通讯作者：
TANJI, J
影响因子：
13.9
作者：
Corbetta M;Shulman GL
通讯作者：
Shulman GL
影响因子：
2.9
作者：
Sosnik R;Flash T;Sterkin A;Hauptmann B;Karni A
通讯作者：
Karni A
影响因子：
2.5
作者：
MATELLI, M;LUPPINO, G;RIZZOLATTI, G
通讯作者：
RIZZOLATTI, G