A cortical filter that learns to suppress the acoustic consequences of movement.
A cortical filter that learns to suppress the acoustic consequences of movement.
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DOI：
10.1038/s41586-018-0520-5
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发表时间：
2018-09
期刊：
影响因子：
64.8
通讯作者：
Mooney R
中科院分区：
文献类型：
--
作者：
Schneider DM;Sundararajan J;Mooney R
声音可能来自环境，也可能来自我们自己的许多动作，例如发声、行走或演奏音乐。预测和区分这些与运动相关的（传入）声音与环境声音的能力对于正常听力至关重要，但学习预测由我们的运动产生的通常任意且多变的声音的神经回路仍然很大程度上未知。在这里，我们开发了一种声学虚拟现实（aVR）系统，在该系统中，小鼠学会将新奇的声音与其运动运动联系起来，使我们能够识别学习抑制传入声音的神经回路机制，并探究这种可预测的感觉运动体验的行为后果。我们发现，aVR 体验逐渐且选择性地抑制听觉皮层对再传入频率的反应，部分是通过加强对再传入音调做出反应的听觉皮层抑制神经元的运动皮层激活。这种可塑性具有行为适应性，因为经历过虚拟现实的小鼠表现出在运动过程中检测非传入音调的能力增强。总之，这些发现描述了一种动态感觉过滤器，涉及运动皮层对听觉皮层的输入，该过滤器可以根据经验进行塑造，以选择性地抑制运动的可预测的声音后果。
Sounds can arise from the environment and also predictably from many of our own movements, such as vocalizing, walking, or playing music. The capacity to anticipate and discriminate these movement-related (reafferent) sounds from environmental sounds is critical to normal hearing, yet the neural circuits that learn to anticipate the often arbitrary and changeable sounds resulting from our movements remain largely unknown. Here we developed an acoustic virtual reality (aVR) system in which a mouse learned to associate a novel sound with its locomotor movements, allowing us to identify the neural circuit mechanisms that learn to suppress reafferent sounds and probe the behavioral consequences of this predictable sensorimotor experience. We found that aVR experience gradually and selectively suppresses auditory cortical responses to the reafferent frequency, in part by strengthening motor cortical activation of auditory cortical inhibitory neurons that respond to the reafferent tone. This plasticity is behaviorally adaptive, as aVR-experienced mice showed an enhanced ability to detect non-reafferent tones during movement. Together, these findings describe a dynamic sensory filter involving motor cortical inputs to the auditory cortex that can be shaped by experience to selectively suppress predictable acoustic consequences of movement.
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影响因子：
16.2
作者：
Fino E;Yuste R
通讯作者：
Yuste R
通过听觉皮层的活跃行为状态减少平衡兴奋和抑制
影响因子：
25
作者：
Zhou, Mu;Liang, Feixue;Xiong, Xiaorui R.;Li, Lu;Li, Haifu;Xiao, Zhongju;Tao, Huizhong W.;Zhang, Li I.
通讯作者：
Zhang, Li I.
影响因子：
25
作者：
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影响因子：
16.2
作者：
McGinley MJ;David SV;McCormick DA
通讯作者：
McCormick DA
影响因子：
25
作者：
Singla S;Dempsey C;Warren R;Enikolopov AG;Sawtell NB
通讯作者：
Sawtell NB