Centriole morphogenesis in developing ciliated epithelium of the mouse oviduct.
Centriole morphogenesis in developing ciliated epithelium of the mouse oviduct.
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DOI：
10.1083/jcb.51.1.286
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发表时间：
1971-10
期刊：
影响因子：
--
通讯作者：
Dirksen ER
中科院分区：
文献类型：
--
作者：
Dirksen ER
分化中的小鼠输卵管上皮具有广泛的纤毛，且中心粒的形成发生在出生后很短的一段时间内，因此已被用于中心粒形态发生的研究。增殖性成分，包括广泛的纤维网状结构，包裹着75mµ颗粒，在所有年龄的动物中都可见，但是年轻动物(2-3天)中唯一存在的中心粒前体。这些大的聚集体要么与成熟的中心粒有物理联系，要么单独存在，但从未与原着丝粒联系在一起。因此，尽管增殖性成分可能来自先前存在的中心粒，但它们并不直接产生新的中心粒。一种中间结构，即凝聚形式，主要存在于老年动物(4-6天)中，由增殖成分材料堆积而产生，产生子代原着丝粒。这种原着丝点和缩合形式的结合被称为生成复合体。凝聚形式经历了耗尽的不同阶段，随着原着丝粒的长度增长并组装它们的微管，产生了具有薄壁的中空球体或小的嗜欧米团聚体。这些观察结果表明，微管前体蛋白的合成是由成熟的中心粒介导的，这种蛋白被包装成多种凝聚形式，以便在短时间内快速组装大量的中心粒。
The differentiating mouse oviduct has been used for the study of centriole morphogenesis because its epithelium is extensively ciliated and centriole formation occurs in a brief period after birth. Proliferative elements, consisting of an extensive fibrillar meshwork encrusted with 75 mµ granules, were encountered at all ages, but were the only centriole precursors present in younger animals (2–3 days). These large aggregates were found either physically associated with a mature centriole or alone, but never associated with procentrioles. It is likely, therefore, that although proliferative elements may be derived from preexisting centrioles, they do not directly produce new centrioles. An intermediate structure, the condensation form, found primarily in older animals (4–6 days), and produced by the packing of the proliferative element material, gives rise to daughter procentrioles. This association of procentriole and condensation form has been called a generative complex. Condensation forms undergo various stages of depletion, producing hollow spheres with thin walls or small osmiophilic aggregates as procentrioles grow in length and assemble their microtubules. From these observations it is concluded that synthesis of microtubular precursor protein is mediated by the mature centriole and that this protein is packaged into many condensation forms in order to allow the rapid assembly of a large number of centrioles in a brief period of time.
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人为激活的海胆卵中的中心元素存在。
DOI：
10.1083/jcb.11.1.244
发表时间：
1961-10
期刊：
The Journal of biophysical and biochemical cytology
影响因子：
--
作者：
DIRKSEN, E R
通讯作者：
DIRKSEN, E R
DOI：
10.1083/jcb.40.3.716
发表时间：
1969-03
期刊：
The Journal of cell biology
影响因子：
--
作者：
Allen RD
通讯作者：
Allen RD
影响因子：
7.8
作者：
OUTKA, DE;KLUSS, BC
通讯作者：
KLUSS, BC
影响因子：
3.6
作者：
FRASCA, JM;AUERBACH, O;STOECKENIUS, W
通讯作者：
STOECKENIUS, W
影响因子：
--
作者：
FRISCH, D;FARBMAN, AI
通讯作者：
FARBMAN, AI