Perirhinal cortex lesions in rats: Novelty detection and sensitivity to interference.
Perirhinal cortex lesions in rats: Novelty detection and sensitivity to interference.
复制标题
DOI：
10.1037/bne0000049
复制
发表时间：
2015-06
影响因子：
1.9
通讯作者：
Aggleton, John P.
中科院分区：
文献类型：
--
作者：
Albasser, Mathieu M.;Olarte-Sanchez, Cristian M.;Amin, Eman;Brown, Malcolm W.;Kinnavane, Lisa;Aggleton, John P.
有嗅周皮层损伤的大鼠在连续的会话中接受多个物体识别试验，以检查它们是否显示错误记忆。实验1主要研究术后第一次物体识别测试中的探索模式，每次测试包含1个新物体和1个熟悉物体。嗅周皮层损伤减少了探索新物体的时间，但不影响探索测试物体（新物体加熟悉物体）的总时间。用随后的大鼠队列进行的重复实验（实验2、3、4.1）重复了这种结果模式。当所有的识别记忆数据相结合（实验1-4），总共有44个嗅周病变大鼠和40个手术假对照，嗅周皮质病变导致总探索时间的边际减少。对新奇事物的时间减少，往往会被对熟悉事物的探索增加所弥补。实验4还评估了前摄干扰对再认记忆的影响。有证据表明，先前的物体经验可能会进一步损害嗅周皮层损伤大鼠的识别性能。实验5检查了探索水平时，大鼠只是给成对的新物体探索。尽管他们的嗅周皮质病变，探索水平与对照组大鼠。虽然实验4的结果支持这样的观点，即嗅周损伤可以增加对前摄干扰的敏感性，但总体研究结果质疑缺乏嗅周皮层的大鼠是否通常表现为对新物体很熟悉，即表现出错误识别。相反，老鼠保留了一个新奇的信号，但很难区分这个信号的身份。
Rats with perirhinal cortex lesions received multiple object recognition trials within a continuous session to examine whether they show false memories. Experiment 1 focused on exploration patterns during the first object recognition test postsurgery, in which each trial contained 1 novel and 1 familiar object. The perirhinal cortex lesions reduced time spent exploring novel objects, but did not affect overall time spent exploring the test objects (novel plus familiar). Replications with subsequent cohorts of rats (Experiments 2, 3, 4.1) repeated this pattern of results. When all recognition memory data were combined (Experiments 1–4), giving totals of 44 perirhinal lesion rats and 40 surgical sham controls, the perirhinal cortex lesions caused a marginal reduction in total exploration time. That decrease in time with novel objects was often compensated by increased exploration of familiar objects. Experiment 4 also assessed the impact of proactive interference on recognition memory. Evidence emerged that prior object experience could additionally impair recognition performance in rats with perirhinal cortex lesions. Experiment 5 examined exploration levels when rats were just given pairs of novel objects to explore. Despite their perirhinal cortex lesions, exploration levels were comparable with those of control rats. While the results of Experiment 4 support the notion that perirhinal lesions can increase sensitivity to proactive interference, the overall findings question whether rats lacking a perirhinal cortex typically behave as if novel objects are familiar, that is, show false recognition. Rather, the rats retain a signal of novelty but struggle to discriminate the identity of that signal.
登录
查看更多内容
影响因子：
2
作者：
Ho, Jonathan Weng-Thim;Narduzzo, Katherine Elizabeth;Brown, Malcolm Watson
通讯作者：
Brown, Malcolm Watson
影响因子：
2.7
作者：
Mumby, Dave G.;Piterkin, Pavel;Lehmann, Hugo
通讯作者：
Lehmann, Hugo
影响因子：
2.7
作者：
ENNACEUR, A;DELACOUR, J
通讯作者：
DELACOUR, J
影响因子：
5.3
作者：
Bartko, Susan J.;Winters, Boyer D.;Bussey, Timothy J.
通讯作者：
Bussey, Timothy J.
DOI：
10.1080/02724990544000004
发表时间：
2005-07-01
期刊：
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
Bussey, TJ;Saksida, LM
通讯作者：
Saksida, LM