The intersection of biological sex and gender in adverse events following seasonal influenza vaccination in older adults.
The intersection of biological sex and gender in adverse events following seasonal influenza vaccination in older adults.
复制标题
DOI：
10.1186/s12979-023-00367-3
复制
发表时间：
2023-08-29
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
对于许多疫苗，包括流感和COVID-19疫苗，女性/女性在免疫接种后报告的不良事件（AE）多于男性/男性。这种差异通常被认为是一种报告偏见，但人们对生物性别和性别的相对贡献知之甚少。我们使用接种后5-8天的AE调查问卷，研究了性别和性别在老年人（≥ 75岁）接种高剂量季节性流感疫苗后AE发生率中的作用。参与者性别（男性或女性）通过自我报告确定，并使用性别评分问卷将参与者分配到四个性别类别（女性，男性，雌雄同体或未分化）中的一个。在接种疫苗前采集的血浆样本中测量性类固醇激素和炎性细胞因子，以生成关于报告AE的生物学机制的假设。在四个流感季节（2019-22）中，173名参与者共接种了423种疫苗，其中339种疫苗（2020-22）的性别数据可用。在105次疫苗接种（25%）后，23名男性和82名女性报告了至少1起AE。大多数AE发生在注射部位，为轻度和一过性。女性发生AE的几率是男性的3倍，女性随年龄增长而降低的程度大于男性。然而，性别的影响在统计学上并不显着，这支持了生物性别在AE发生中的核心作用。在男性中，雌二醇与IL-6和发生AE的概率显著相关。这两种相关性在女性中均不存在，表明雌二醇对AE发生的性别特异性影响支持生物学性别差异的发现。这些数据支持生物学性别在老年人流感疫苗接种后AE发生中的作用大于性别，并提供了可能介导这种性别差异的激素机制的初步研究。这项研究强调了测量性别的复杂性，以及分别评估男性和女性AE的重要性，以更好地了解如何针对不同的人群亚群制定疫苗接种策略。在线版本包含补充材料，可通过10.1186/s12979-023-00367-3获得。
Women/females report more adverse events (AE) following immunization than men/males for many vaccines, including the influenza and COVID-19 vaccines. This discrepancy is often dismissed as a reporting bias, yet the relative contributions of biological sex and gender are poorly understood. We investigated the roles of sex and gender in the rate of AE following administration of the high-dose seasonal influenza vaccine to older adults (≥ 75 years) using an AE questionnaire administered 5–8 days post-vaccination. Participant sex (male or female) was determined by self-report and a gender score questionnaire was used to assign participants to one of four gender categories (feminine, masculine, androgynous, or undifferentiated). Sex steroid hormones and inflammatory cytokines were measured in plasma samples collected prior to vaccination to generate hypotheses as to the biological mechanism underpinning the AE reported. A total of 423 vaccines were administered to 173 participants over four influenza seasons (2019-22) and gender data were available for 339 of these vaccinations (2020-22). At least one AE was reported following 105 vaccinations (25%), by 23 males and 82 females. The majority of AE occurred at the site of injection, were mild, and transient. The odds of experiencing an AE were 3-fold greater in females than males and decreased with age to a greater extent in females than males. The effects of gender, however, were not statistically significant, supporting a central role of biological sex in the occurrence of AE. In males, estradiol was significantly associated with IL-6 and with the probability of experiencing an AE. Both associations were absent in females, suggesting a sex-specific effect of estradiol on the occurrence of AE that supports the finding of a biological sex difference. These data support a larger role for biological sex than for gender in the occurrence of AE following influenza vaccination in older adults and provide an initial investigation of hormonal mechanisms that may mediate this sex difference. This study highlights the complexities of measuring gender and the importance of assessing AE separately for males and females to better understand how vaccination strategies can be tailored to different subsets of the population. The online version contains supplementary material available at 10.1186/s12979-023-00367-3.
登录
查看更多内容
DOI：
10.3390/ijerph19052563
发表时间：
2022-02-23
影响因子：
--
作者：
Greaves L;Ritz SA
通讯作者：
Ritz SA
影响因子：
7.8
作者：
Hoffmann MA;Wieler HJ;Enders P;Buchholz HG;Plachter B
通讯作者：
Plachter B
影响因子：
6.2
作者：
Azizi, Zahra;Gisinger, Teresa;Pilote, Louise
通讯作者：
Pilote, Louise
影响因子：
6.4
作者：
Klein, Sabra L.;Pekosz, Andrew
通讯作者：
Pekosz, Andrew
影响因子：
5
作者：
Hart, Chloe Grace;Saperstein, Aliya;Westbrook, Laurel
通讯作者：
Westbrook, Laurel